TY - JOUR
T1 - Dietary influences on symptomatic and non-symptomatic toxicities during cancer treatment
T2 - A narrative review
AU - Kim, Alan J.
AU - Hong, David S.
AU - George, Goldy C.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/7
Y1 - 2022/7
N2 - The general nutritional status of cancer patients could be a central determinant of cancer treatment-related toxicity and an indicator of cancer symptoms such as cancer-related cachexia and weight loss. This narrative scientific review covers the impact of dietary patterns (for example, Mediterranean diet, short-term fasting, ketogenic diet), dietary components (for example, fruits and vegetables, fish oils, turmeric/curcumin, dietary fiber, phytochemicals, vitamin/mineral dietary supplements), and the gut microbiota on symptoms, toxicities, and adverse events associated with cancer treatment. Although several studies have produced controversial or inconclusive results, some promising preclinical studies and initial clinical trials suggest that dietary interventions may alleviate certain cancer treatment-related symptoms and toxicities. Possible mechanisms by which dietary components may influence symptomatic and non-symptomatic toxicities during cancer treatment include through impacting inflammation, oxidative stress, muscle mass, cardiac health and regulating the gut microbiome. Current ongoing studies will continue to shed light on whether specific dietary interventions, with a special emphasis on the gut microbiota, are an effective method to improve cancer treatment outcomes. Future studies should examine the synergistic effects of combining different nutritional interventions and establish diet-related guidelines for cancer treatment.
AB - The general nutritional status of cancer patients could be a central determinant of cancer treatment-related toxicity and an indicator of cancer symptoms such as cancer-related cachexia and weight loss. This narrative scientific review covers the impact of dietary patterns (for example, Mediterranean diet, short-term fasting, ketogenic diet), dietary components (for example, fruits and vegetables, fish oils, turmeric/curcumin, dietary fiber, phytochemicals, vitamin/mineral dietary supplements), and the gut microbiota on symptoms, toxicities, and adverse events associated with cancer treatment. Although several studies have produced controversial or inconclusive results, some promising preclinical studies and initial clinical trials suggest that dietary interventions may alleviate certain cancer treatment-related symptoms and toxicities. Possible mechanisms by which dietary components may influence symptomatic and non-symptomatic toxicities during cancer treatment include through impacting inflammation, oxidative stress, muscle mass, cardiac health and regulating the gut microbiome. Current ongoing studies will continue to shed light on whether specific dietary interventions, with a special emphasis on the gut microbiota, are an effective method to improve cancer treatment outcomes. Future studies should examine the synergistic effects of combining different nutritional interventions and establish diet-related guidelines for cancer treatment.
KW - Cancer
KW - Diet
KW - Microbiome
KW - Nutrition
KW - Symptom
KW - Toxicities
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U2 - 10.1016/j.ctrv.2022.102408
DO - 10.1016/j.ctrv.2022.102408
M3 - Review article
C2 - 35623220
AN - SCOPUS:85130600047
SN - 0305-7372
VL - 108
JO - Cancer treatment reviews
JF - Cancer treatment reviews
M1 - 102408
ER -