TY - JOUR
T1 - DNA-damage checkpoints
T2 - location, location, location
AU - Wood, Jamie L.
AU - Chen, Junjie
PY - 2008/10
Y1 - 2008/10
N2 - The DNA-damage response (DDR) is an evolutionarily conserved signaling cascade crucial for sensing DNA damage and activating cellular responses such as cell-cycle arrest, DNA repair, senescence and apoptosis. Excitingly, two recent studies describe activation of this checkpoint in the absence of DNA damage. These studies support the idea that accumulation of checkpoint proteins and changes in global-chromatin structure are important signaling intermediates for the activation of the DDR.
AB - The DNA-damage response (DDR) is an evolutionarily conserved signaling cascade crucial for sensing DNA damage and activating cellular responses such as cell-cycle arrest, DNA repair, senescence and apoptosis. Excitingly, two recent studies describe activation of this checkpoint in the absence of DNA damage. These studies support the idea that accumulation of checkpoint proteins and changes in global-chromatin structure are important signaling intermediates for the activation of the DDR.
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U2 - 10.1016/j.tcb.2008.07.006
DO - 10.1016/j.tcb.2008.07.006
M3 - Short survey
C2 - 18760607
AN - SCOPUS:52949144228
SN - 0962-8924
VL - 18
SP - 451
EP - 455
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 10
ER -