Dysregulation of HIF2α and autophagy in renal cell carcinoma

Xian De Liu; Haifeng Zhu; Adela DePavia; Eric Jonasch

doi:10.4161/23723548.2014.965643

Dysregulation of HIF2α and autophagy in renal cell carcinoma

Xian De Liu, Haifeng Zhu, Adela DePavia, Eric Jonasch

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).

Original language	English (US)
Article number	e965643
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/23723548.2014.965643
State	Published - Apr 3 2015

Keywords

HIF2α
VHL
autophagy
p53
p62
proteasome
renal cell carcinoma

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723548.2014.965643

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title = "Dysregulation of HIF2α and autophagy in renal cell carcinoma",

abstract = "Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).",

keywords = "HIF2α, VHL, autophagy, p53, p62, proteasome, renal cell carcinoma",

author = "Liu, {Xian De} and Haifeng Zhu and Adela DePavia and Eric Jonasch",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Xian-De Liu, Haifeng Zhu, Adela DePavia, and Eric Jonasch.",

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AU - Zhu, Haifeng

AU - DePavia, Adela

AU - Jonasch, Eric

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AB - Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).

KW - HIF2α

KW - VHL

KW - autophagy

KW - p53

KW - p62

KW - proteasome

KW - renal cell carcinoma

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Dysregulation of HIF2α and autophagy in renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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