TY - JOUR
T1 - Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues
AU - Porter, Dale
AU - Lahti-Domenici, Jaana
AU - Torres-Arzayus, Marisa
AU - Chin, Lynda
AU - Polyak, Kornelia
N1 - Funding Information:
We thank Dr Myles Brown for providing DNA complementary to RNA (cDNA) for Fig. 1D , and Drs Ramesh Shivdasani and Ian Krop for critical reading of the manuscript. This work was supported by an ASCO (American Society of Clinical Oncology) Career Development Award and Dana-Farber Cancer Institute (K.P.).
PY - 2002
Y1 - 2002
N2 - We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression of both genes was detected only at E17.5-18.5 and the HIN-1 messenger RNA was localized to the epithelia of the trachea, bronchi, and uterine glands. The expression of HIN-1 is up-regulated during retinoic acid induced differentiation of bronchial epithelial cells. We also identified two putative Drosophila HIN-1 homologues. The expression of HIN-1 is restricted to terminally differentiated airway epithelial cells in vivo and in vitro implicating HIN-1 in the acquisition or maintenance of terminally differentiated epithelial phenotype.
AB - We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression of both genes was detected only at E17.5-18.5 and the HIN-1 messenger RNA was localized to the epithelia of the trachea, bronchi, and uterine glands. The expression of HIN-1 is up-regulated during retinoic acid induced differentiation of bronchial epithelial cells. We also identified two putative Drosophila HIN-1 homologues. The expression of HIN-1 is restricted to terminally differentiated airway epithelial cells in vivo and in vitro implicating HIN-1 in the acquisition or maintenance of terminally differentiated epithelial phenotype.
KW - C/EBP-δ
KW - Development
KW - Differentiation
KW - Drosophila
KW - Epithelium
KW - High in normal-1 (HIN-1)
KW - Lung
KW - Mammary gland
KW - Retinoic acid
KW - Secretoglobin
KW - Trachea
KW - Uteroglobin
KW - Uteroglobin related protein-1 (URGP-1)
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U2 - 10.1016/S0925-4773(02)00056-4
DO - 10.1016/S0925-4773(02)00056-4
M3 - Article
C2 - 12175512
AN - SCOPUS:0036011265
SN - 0925-4773
VL - 114
SP - 201
EP - 204
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 1-2
ER -