Extramedullary relapse in a patient with acute promyelocytic leukemia: Successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies

Apostolia Maria Tsimberidou; Elihu Estey; Gary J. Whitman; Mark J. Dryden; Suresh Ratnam; Sherry Pierce; Stefan Faderl; Francis Giles; Hagop M. Kantarjian; Guillermo Garcia-Manero

doi:10.1016/j.leukres.2004.01.004

Extramedullary relapse in a patient with acute promyelocytic leukemia: Successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies

Apostolia Maria Tsimberidou, Elihu Estey, Gary J. Whitman, Mark J. Dryden, Suresh Ratnam, Sherry Pierce, Stefan Faderl, Francis Giles, Hagop M. Kantarjian, Guillermo Garcia-Manero

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Acute promyelocytic leukemia (APL) is characterized by the presence of the t(15;17) translocation, resulting in the PML-RAR fusion protein. Standard treatment consists of the combination of all-trans retinoic acid (ATRA) with an anthracycline that results in complete remission (CR) rates in excess of 90%. Recently, several new agents have been shown to have clinical activity in APL. These include a liposomal formulation of ATRA (lipo-ATRA), and gemtuzumab ozogamicin (GO). Herein, we report a patient with APL who relapsed with extramedullary disease 2.5 years after lipo-ATRA therapy and was successfully treated with the sequence of A₂O₃, ATRA, and GO and we summarize our experience with patients with isolated extramedullary relapse in APL.

Original language	English (US)
Pages (from-to)	991-994
Number of pages	4
Journal	Leukemia Research
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2004.01.004
State	Published - Sep 2004

Keywords

APL
ATRA
Extramedullary relapse

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2004.01.004

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Tsimberidou, A. M., Estey, E., Whitman, G. J., Dryden, M. J., Ratnam, S., Pierce, S., Faderl, S., Giles, F., Kantarjian, H. M., & Garcia-Manero, G. (2004). Extramedullary relapse in a patient with acute promyelocytic leukemia: Successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies. Leukemia Research, 28(9), 991-994. https://doi.org/10.1016/j.leukres.2004.01.004

Extramedullary relapse in a patient with acute promyelocytic leukemia: Successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies. / Tsimberidou, Apostolia Maria; Estey, Elihu; Whitman, Gary J. et al.
In: Leukemia Research, Vol. 28, No. 9, 09.2004, p. 991-994.

Research output: Contribution to journal › Article › peer-review

Tsimberidou, AM, Estey, E, Whitman, GJ , Dryden, MJ, Ratnam, S, Pierce, S, Faderl, S, Giles, F, Kantarjian, HM & Garcia-Manero, G 2004, 'Extramedullary relapse in a patient with acute promyelocytic leukemia: Successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies', Leukemia Research, vol. 28, no. 9, pp. 991-994. https://doi.org/10.1016/j.leukres.2004.01.004

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abstract = "Acute promyelocytic leukemia (APL) is characterized by the presence of the t(15;17) translocation, resulting in the PML-RAR fusion protein. Standard treatment consists of the combination of all-trans retinoic acid (ATRA) with an anthracycline that results in complete remission (CR) rates in excess of 90%. Recently, several new agents have been shown to have clinical activity in APL. These include a liposomal formulation of ATRA (lipo-ATRA), and gemtuzumab ozogamicin (GO). Herein, we report a patient with APL who relapsed with extramedullary disease 2.5 years after lipo-ATRA therapy and was successfully treated with the sequence of A2O3, ATRA, and GO and we summarize our experience with patients with isolated extramedullary relapse in APL.",

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AU - Whitman, Gary J.

AU - Dryden, Mark J.

AU - Ratnam, Suresh

AU - Pierce, Sherry

AU - Faderl, Stefan

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Extramedullary relapse in a patient with acute promyelocytic leukemia: Successful treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies

Abstract

Keywords

ASJC Scopus subject areas

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