TY - JOUR
T1 - Field carcinogenesis in cancer evolution
T2 - What the cell is going on?
AU - Sinjab, Ansam
AU - Han, Guangchun
AU - Wang, Linghua
AU - Kadara, Humam
N1 - Funding Information:
H. Kadara reports grants from Johnson and Johnson outside the submitted work. No potential conflicts of interest were disclosed by the other authors.
Publisher Copyright:
© 2020 American Association for Cancer Research.
PY - 2020/11/15
Y1 - 2020/11/15
N2 - Field carcinogenesis describes the prevalence of tumor-related alterations in normal appearing tissues. Here, we summarize recent efforts in profiling molecular field dynamics for resolving early events in cancer evolution. We also highlight gaps in our knowledge of the molecular and cellular heterogeneity of field carcinogenesis and propose directions to tackle these voids using single-cell-based approaches and unique tissue sampling models. By interrogating both the mutagenized epithelium and its microenvironment, we surmise that single-cell-guided studies will help chart the spatiotemporal molecular and cellular "atlas"of field carcinogenesis, will further delineate preneoplastic initiation and progression, and will help identify cancer prevention and early intervention targets.
AB - Field carcinogenesis describes the prevalence of tumor-related alterations in normal appearing tissues. Here, we summarize recent efforts in profiling molecular field dynamics for resolving early events in cancer evolution. We also highlight gaps in our knowledge of the molecular and cellular heterogeneity of field carcinogenesis and propose directions to tackle these voids using single-cell-based approaches and unique tissue sampling models. By interrogating both the mutagenized epithelium and its microenvironment, we surmise that single-cell-guided studies will help chart the spatiotemporal molecular and cellular "atlas"of field carcinogenesis, will further delineate preneoplastic initiation and progression, and will help identify cancer prevention and early intervention targets.
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U2 - 10.1158/0008-5472.CAN-20-1956
DO - 10.1158/0008-5472.CAN-20-1956
M3 - Article
C2 - 33023945
AN - SCOPUS:85100314640
SN - 0008-5472
VL - 80
SP - 4888
EP - 4891
JO - Cancer Research
JF - Cancer Research
IS - 22
ER -