Abstract
Non-small cell lung carcinoma is a leading cause of cancer death worldwide. Understanding the molecular biology of survival and proliferation of cancer cells led to a new molecular classification of lung cancer and the development of targeted therapies with promising results. With the advances of image-guided biopsy techniques, tumor samples are becoming smaller, and the molecular testing techniques have to overcome the challenge of integrating the characterization of a panel of abnormalities including gene mutations, copy-number changes, and fusions in a reduced number of assays using only a small amount of genetic material. This article reviews the current knowledge about the most frequent actionable molecular abnormalities in non-small cell lung carcinoma, the new approaches of molecular analysis, and the implications of these findings in the context of clinical practice.
Original language | English (US) |
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Pages (from-to) | 413-424 |
Number of pages | 12 |
Journal | Cancer Journal (United States) |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 2015 |
Keywords
- Biomarkers
- Lung cancer
- Molecular profiling
- Multiplex testing
- NSCLC
- Next-generation sequencing
- Oncogenic drivers
ASJC Scopus subject areas
- Oncology
- Cancer Research