H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

Emily Z. Keung; Kunal Rai

doi:10.1080/23723556.2015.1093691

H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

Emily Z. Keung, Kunal Rai

Genomic Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.

Original language	English (US)
Article number	e1093691
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2015.1093691
State	Published - May 3 2016

Keywords

Dedifferentiated
H3K9me3
KLF6
epigenetics
liposarcoma
well differentiated

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

Access to Document

10.1080/23723556.2015.1093691

Cite this

@article{283dd74d803d4038af9e8815be46eb4a,

title = "H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach",

abstract = "The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.",

keywords = "Dedifferentiated, H3K9me3, KLF6, epigenetics, liposarcoma, well differentiated",

author = "Keung, {Emily Z.} and Kunal Rai",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor & Francis Group, LLC.",

year = "2016",

month = may,

day = "3",

doi = "10.1080/23723556.2015.1093691",

language = "English (US)",

volume = "3",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - H3K9me3-mediated repression of KLF6

T2 - Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

AU - Keung, Emily Z.

AU - Rai, Kunal

PY - 2016/5/3

Y1 - 2016/5/3

N2 - The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.

AB - The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.

KW - Dedifferentiated

KW - H3K9me3

KW - KLF6

KW - epigenetics

KW - liposarcoma

KW - well differentiated

UR - http://www.scopus.com/inward/record.url?scp=85050772758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050772758&partnerID=8YFLogxK

U2 - 10.1080/23723556.2015.1093691

DO - 10.1080/23723556.2015.1093691

M3 - Article

C2 - 27314083

AN - SCOPUS:85050772758

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e1093691

ER -

H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this