TY - JOUR
T1 - Impact of tissue-agnostic approvals for patients with gastrointestinal malignancies
AU - Bhamidipati, Deepak
AU - Subbiah, Vivek
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2023/3
Y1 - 2023/3
N2 - Gastrointestinal (GI) malignancies encompass a broad range of tumors with limited treatment options, particularly for advanced disease. With the development and implementation of next-generation sequencing (NGS) in routine practice, molecular-targeting therapies have been increasingly incorporated into the treatment paradigm for various cancers. Several drugs have achieved tissue-agnostic regulatory approvals, which offer promising biomarker-driven therapy options for patients with advanced GI malignancies. In this review, we focus on the clinical evidence for recent drug approvals for neurotrophic tyrosine receptor kinase (NTRK) fusion, microsatellite instability-high (MSI-H) phenotype, tumor mutation burden-high (TMB-H), BRAF V600E, and rearranged during transfection (RET), in the context of GI malignancies. We also highlight the future landscape of tissue-agnostic targets, such as human epidermal growth factor receptor 2 (HER2)/neu, fibroblast growth factor receptor (FGFR), and neuregulin (NRG)-1.
AB - Gastrointestinal (GI) malignancies encompass a broad range of tumors with limited treatment options, particularly for advanced disease. With the development and implementation of next-generation sequencing (NGS) in routine practice, molecular-targeting therapies have been increasingly incorporated into the treatment paradigm for various cancers. Several drugs have achieved tissue-agnostic regulatory approvals, which offer promising biomarker-driven therapy options for patients with advanced GI malignancies. In this review, we focus on the clinical evidence for recent drug approvals for neurotrophic tyrosine receptor kinase (NTRK) fusion, microsatellite instability-high (MSI-H) phenotype, tumor mutation burden-high (TMB-H), BRAF V600E, and rearranged during transfection (RET), in the context of GI malignancies. We also highlight the future landscape of tissue-agnostic targets, such as human epidermal growth factor receptor 2 (HER2)/neu, fibroblast growth factor receptor (FGFR), and neuregulin (NRG)-1.
KW - cancer clinical trials
KW - next-generation sequencing
KW - targeted therapy
KW - tissue-agnostic
UR - http://www.scopus.com/inward/record.url?scp=85143982032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85143982032&partnerID=8YFLogxK
U2 - 10.1016/j.trecan.2022.11.003
DO - 10.1016/j.trecan.2022.11.003
M3 - Review article
C2 - 36494311
AN - SCOPUS:85143982032
SN - 2405-8033
VL - 9
SP - 237
EP - 249
JO - Trends in Cancer
JF - Trends in Cancer
IS - 3
ER -