TY - JOUR
T1 - Interaction of aldehydes derived from lipid peroxidation and membrane proteins
AU - Pizzimenti, Stefania
AU - Ciamporcero, Eric
AU - Daga, Martina
AU - Pettazzoni, Piergiorgio
AU - Arcaro, Alessia
AU - Cetrangolo, Gianpaolo
AU - Minelli, Rosalba
AU - Dianzani, Chiara
AU - Lepore, Alessio
AU - Gentile, Fabrizio
AU - Barrera, Giuseppina
PY - 2013
Y1 - 2013
N2 - A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4-hydroxyalkenals, malondialdehyde (MDA) and acrolein, have received particular attention since they have been considered as toxic messengers that can propagate and amplify oxidative injury. In the 4-hydroxyalkenal class, 4-hydroxy-2-nonenal (HNE) is the most intensively studied aldehyde, in relation not only to its toxic function, but also to its physiological role. Indeed, HNE can be found at low concentrations in human tissues and plasma and participates in the control of biological processes, such as signal transduction, cell proliferation, and differentiation. Moreover, at low doses, HNE exerts an anticancer effect, by inhibiting cell proliferation, angiogenesis, cell adhesion and by inducing differentiation and/or apoptosis in various tumor cell lines. It is very likely that a substantial fraction of the effects observed in cellular responses, induced by HNE and related aldehydes, be mediated by their interaction with proteins, resulting in the formation of covalent adducts or in the modulation of their expression and/or activity. In this review we focus on membrane proteins affected by lipid peroxidation-derived aldehydes, under physiological and pathological conditions.
AB - A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4-hydroxyalkenals, malondialdehyde (MDA) and acrolein, have received particular attention since they have been considered as toxic messengers that can propagate and amplify oxidative injury. In the 4-hydroxyalkenal class, 4-hydroxy-2-nonenal (HNE) is the most intensively studied aldehyde, in relation not only to its toxic function, but also to its physiological role. Indeed, HNE can be found at low concentrations in human tissues and plasma and participates in the control of biological processes, such as signal transduction, cell proliferation, and differentiation. Moreover, at low doses, HNE exerts an anticancer effect, by inhibiting cell proliferation, angiogenesis, cell adhesion and by inducing differentiation and/or apoptosis in various tumor cell lines. It is very likely that a substantial fraction of the effects observed in cellular responses, induced by HNE and related aldehydes, be mediated by their interaction with proteins, resulting in the formation of covalent adducts or in the modulation of their expression and/or activity. In this review we focus on membrane proteins affected by lipid peroxidation-derived aldehydes, under physiological and pathological conditions.
KW - Aldehydes
KW - Human diseases
KW - Lipid peroxidation
KW - Membrane proteins
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=84884554443&partnerID=8YFLogxK
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U2 - 10.3389/fphys.2013.00242
DO - 10.3389/fphys.2013.00242
M3 - Review article
C2 - 24027536
AN - SCOPUS:84884554443
SN - 1664-042X
VL - 4 SEP
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - Article 242
ER -