Abstract
Inflammation is associated with cancer initiation, progression, angiogenesis, and metastasis. The major proinflammatory cytokine interleukin-1 (IL-1) is involved in all aspects of carcinogenesis. Indeed, recent studies have showed a crucial role of IL-1 in the suppression of the antitumor immune response, resulting in tumor resistance to immunotherapy. In this chapter, we discuss the mechanisms of IL-1 production in the tumor microenvironment, IL-1-mediated immune suppression in various tumors, and IL-1-mediated resistance to immunotherapy.
| Original language | English (US) |
|---|---|
| Title of host publication | Multifaceted Role of IL-1 in Cancer and Inflammation |
| Publisher | Elsevier |
| Pages | 87-98 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780128242735 |
| ISBN (Print) | 9780323859677 |
| DOIs | |
| State | Published - Jan 1 2023 |
Keywords
- DAMPs
- Immune checkpoint blockade
- Interleukin-1
- PAMPs
- Proinflammatory cytokine
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology