Interleukin-10 in cancer immunotherapy: from bench to bedside

Mohamad Adham Salkeni; Aung Naing

doi:10.1016/j.trecan.2023.05.003

Interleukin-10 in cancer immunotherapy: from bench to bedside

Mohamad Adham Salkeni, Aung Naing

Investigational Cancer Therapeutics

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its functionality in promoting antitumor immunity was described more recently. Context- and concentration-dependent biological effects are the hallmarks of the pleiotropic role of IL-10. Despite reducing tumor-promoting inflammation, IL-10 may have a role in rejuvenating exhausted tumor-resident T cells. Contrary to the assumption that IL-10 produces an immunosuppressive tumor microenvironment (TME), it promotes activation of tumor-resident CD8+ T cells, which aids tumor rejection. Emerging data from published early-Phase trials have shown mixed results in different tumor types. In this review, we summarize the biological effects of IL-10 and highlight the clinical experience using pegilodecakin.

Original language	English (US)
Pages (from-to)	716-725
Number of pages	10
Journal	Trends in Cancer
Volume	9
Issue number	9
DOIs	https://doi.org/10.1016/j.trecan.2023.05.003
State	Published - Sep 2023

Keywords

cancer
inflammation
interleukin 10
pegilodecakin
pegylated IL-10
T cell

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2023.05.003

Cite this

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title = "Interleukin-10 in cancer immunotherapy: from bench to bedside",

abstract = "Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its functionality in promoting antitumor immunity was described more recently. Context- and concentration-dependent biological effects are the hallmarks of the pleiotropic role of IL-10. Despite reducing tumor-promoting inflammation, IL-10 may have a role in rejuvenating exhausted tumor-resident T cells. Contrary to the assumption that IL-10 produces an immunosuppressive tumor microenvironment (TME), it promotes activation of tumor-resident CD8+ T cells, which aids tumor rejection. Emerging data from published early-Phase trials have shown mixed results in different tumor types. In this review, we summarize the biological effects of IL-10 and highlight the clinical experience using pegilodecakin.",

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AU - Naing, Aung

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N2 - Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its functionality in promoting antitumor immunity was described more recently. Context- and concentration-dependent biological effects are the hallmarks of the pleiotropic role of IL-10. Despite reducing tumor-promoting inflammation, IL-10 may have a role in rejuvenating exhausted tumor-resident T cells. Contrary to the assumption that IL-10 produces an immunosuppressive tumor microenvironment (TME), it promotes activation of tumor-resident CD8+ T cells, which aids tumor rejection. Emerging data from published early-Phase trials have shown mixed results in different tumor types. In this review, we summarize the biological effects of IL-10 and highlight the clinical experience using pegilodecakin.

AB - Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its functionality in promoting antitumor immunity was described more recently. Context- and concentration-dependent biological effects are the hallmarks of the pleiotropic role of IL-10. Despite reducing tumor-promoting inflammation, IL-10 may have a role in rejuvenating exhausted tumor-resident T cells. Contrary to the assumption that IL-10 produces an immunosuppressive tumor microenvironment (TME), it promotes activation of tumor-resident CD8+ T cells, which aids tumor rejection. Emerging data from published early-Phase trials have shown mixed results in different tumor types. In this review, we summarize the biological effects of IL-10 and highlight the clinical experience using pegilodecakin.

KW - cancer

KW - inflammation

KW - interleukin 10

KW - pegilodecakin

KW - pegylated IL-10

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Interleukin-10 in cancer immunotherapy: from bench to bedside

Abstract

Keywords

ASJC Scopus subject areas

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