Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes

John C. Rasmussen; Funda Meric-Berstam; Savitri Krishnamurthy; I. Chih Tan; Banghe Zhu; Jamie L. Wagner; Gildy V. Babiera; Elizabeth A. Mittendorf; Eva M. Sevick-Muraca

doi:10.1117/12.2057640

Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes

John C. Rasmussen, Funda Meric-Berstam, Savitri Krishnamurthy, I. Chih Tan, Banghe Zhu, Jamie L. Wagner, Gildy V. Babiera, Elizabeth A. Mittendorf, Eva M. Sevick-Muraca

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this proof-of-concept study we seek to demonstrate the delivery of fluorescent contrast agent to the tumor-draining lymph node basin following intraparenchymal breast injections and intradermal arm injection of micrograms of indocyanine green in 20 breast cancer patients undergoing complete axillary lymph node dissection. Individual lymph nodes were assessed ex vivo for presence of fluorescent signal. In all, 88% of tumor-negative lymph nodes and 81% of tumor-positive lymph nodes were fluorescent. These results indicate that future studies utilizing targeted fluorescent contrast agents may demonstrate improved surgical and therapeutic intervention..

Original language	English (US)
Title of host publication	Translational Biophotonics
Publisher	SPIE
ISBN (Print)	9780819496263
DOIs	https://doi.org/10.1117/12.2057640
State	Published - 2014
Event	Translational Biophotonics - Houston, TX, United States Duration: May 19 2014 → May 20 2014

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9155
ISSN (Print)	1605-7422

Other

Other	Translational Biophotonics
Country/Territory	United States
City	Houston, TX
Period	5/19/14 → 5/20/14

Keywords

Near-infrared fluorescence
image analysis
indocyanine green
lymphatic imaging
solid phantom

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1117/12.2057640

Cite this

Rasmussen, J. C., Meric-Berstam, F., Krishnamurthy, S., Tan, I. C., Zhu, B., Wagner, J. L., Babiera, G. V., Mittendorf, E. A., & Sevick-Muraca, E. M. (2014). Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes. In Translational Biophotonics Article 91550O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9155). SPIE. https://doi.org/10.1117/12.2057640

Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes. / Rasmussen, John C.; Meric-Berstam, Funda ; Krishnamurthy, Savitri et al.
Translational Biophotonics. SPIE, 2014. 91550O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9155).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Rasmussen, JC, Meric-Berstam, F , Krishnamurthy, S, Tan, IC, Zhu, B, Wagner, JL, Babiera, GV, Mittendorf, EA & Sevick-Muraca, EM 2014, Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes. in Translational Biophotonics., 91550O, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9155, SPIE, Translational Biophotonics, Houston, TX, United States, 5/19/14. https://doi.org/10.1117/12.2057640

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title = "Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes",

abstract = "In this proof-of-concept study we seek to demonstrate the delivery of fluorescent contrast agent to the tumor-draining lymph node basin following intraparenchymal breast injections and intradermal arm injection of micrograms of indocyanine green in 20 breast cancer patients undergoing complete axillary lymph node dissection. Individual lymph nodes were assessed ex vivo for presence of fluorescent signal. In all, 88% of tumor-negative lymph nodes and 81% of tumor-positive lymph nodes were fluorescent. These results indicate that future studies utilizing targeted fluorescent contrast agents may demonstrate improved surgical and therapeutic intervention..",

keywords = "Near-infrared fluorescence, image analysis, indocyanine green, lymphatic imaging, solid phantom",

author = "Rasmussen, {John C.} and Funda Meric-Berstam and Savitri Krishnamurthy and Tan, {I. Chih} and Banghe Zhu and Wagner, {Jamie L.} and Babiera, {Gildy V.} and Mittendorf, {Elizabeth A.} and Sevick-Muraca, {Eva M.}",

year = "2014",

doi = "10.1117/12.2057640",

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AU - Rasmussen, John C.

AU - Meric-Berstam, Funda

AU - Krishnamurthy, Savitri

AU - Tan, I. Chih

AU - Zhu, Banghe

AU - Wagner, Jamie L.

AU - Babiera, Gildy V.

AU - Mittendorf, Elizabeth A.

AU - Sevick-Muraca, Eva M.

PY - 2014

Y1 - 2014

N2 - In this proof-of-concept study we seek to demonstrate the delivery of fluorescent contrast agent to the tumor-draining lymph node basin following intraparenchymal breast injections and intradermal arm injection of micrograms of indocyanine green in 20 breast cancer patients undergoing complete axillary lymph node dissection. Individual lymph nodes were assessed ex vivo for presence of fluorescent signal. In all, 88% of tumor-negative lymph nodes and 81% of tumor-positive lymph nodes were fluorescent. These results indicate that future studies utilizing targeted fluorescent contrast agents may demonstrate improved surgical and therapeutic intervention..

AB - In this proof-of-concept study we seek to demonstrate the delivery of fluorescent contrast agent to the tumor-draining lymph node basin following intraparenchymal breast injections and intradermal arm injection of micrograms of indocyanine green in 20 breast cancer patients undergoing complete axillary lymph node dissection. Individual lymph nodes were assessed ex vivo for presence of fluorescent signal. In all, 88% of tumor-negative lymph nodes and 81% of tumor-positive lymph nodes were fluorescent. These results indicate that future studies utilizing targeted fluorescent contrast agents may demonstrate improved surgical and therapeutic intervention..

KW - Near-infrared fluorescence

KW - image analysis

KW - indocyanine green

KW - lymphatic imaging

KW - solid phantom

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DO - 10.1117/12.2057640

M3 - Conference contribution

AN - SCOPUS:84906309204

SN - 9780819496263

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Translational Biophotonics

PB - SPIE

T2 - Translational Biophotonics

Y2 - 19 May 2014 through 20 May 2014

ER -

Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes

Abstract

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Keywords

ASJC Scopus subject areas

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