Abstract
We reported that histone H3 lysine (K) 4 methyltransferase, KMT2D, serves as a potent tumor-suppressor in melanoma, which was identified via in vivo epigenome-focused RNA interference (RNAi) screen. KMT2D-deficient tumors show substantial reprogramming of key metabolic pathways including glycolysis via reduction of H3K4me1 (Histone H3K4 mono-methylation)-marked active enhancers, conferring sensitivity to inhibitors of glycolysis and IGFR (Insulin Growth Factor Receptor) pathway.
Original language | English (US) |
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Article number | 1984827 |
Journal | Molecular and Cellular Oncology |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - 2021 |
Keywords
- KMT2D
- enhancer reprogramming
- glycolysis
- melanoma
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research