Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

Wei Zhao; Jun Li; Mei Ju M. Chen; Yikai Luo; Zhenlin Ju; Nicole K. Nesser; Katie Johnson-Camacho; Christopher T. Boniface; Yancey Lawrence; Nupur T. Pande; Michael A. Davies; Meenhard Herlyn; Taru Muranen; Ioannis K. Zervantonakis; Erika von Euw; Andre Schultz; Shwetha V. Kumar; Anil Korkut; Paul T. Spellman; Rehan Akbani; Dennis J. Slamon; Joe W. Gray; Joan S. Brugge; Yiling Lu; Gordon B. Mills; Han Liang

doi:10.1016/j.ccell.2020.10.008

Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

Wei Zhao, Jun Li, Mei Ju M. Chen, Yikai Luo, Zhenlin Ju, Nicole K. Nesser, Katie Johnson-Camacho, Christopher T. Boniface, Yancey Lawrence, Nupur T. Pande, Michael A. Davies, Meenhard Herlyn, Taru Muranen, Ioannis K. Zervantonakis, Erika von Euw, Andre Schultz, Shwetha V. Kumar, Anil Korkut, Paul T. Spellman, Rehan AkbaniDennis J. Slamon, Joe W. Gray, Joan S. Brugge, Yiling Lu, Gordon B. Mills, Han Liang

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Zhao et al. profile the protein responses of a large collection of cancer cell lines to drug perturbations using the RPPA platform and build a systematic protein-drug connectivity map. The integration of perturbed protein responses provides better prediction of drug sensitivity and insights into drug-resistance mechanisms and combination therapies.

Original language	English (US)
Pages (from-to)	829-843.e4
Journal	Cancer cell
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2020.10.008
State	Published - Dec 14 2020

Keywords

biomarker
cancer signaling pathway
drug response
protein array

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

MD Anderson CCSG core facilities

Bioinformatics Shared Resource
Functional Proteomics Reverse Phase Protein Array Core

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10.1016/j.ccell.2020.10.008

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Zhao, W., Li, J., Chen, M. J. M., Luo, Y., Ju, Z., Nesser, N. K., Johnson-Camacho, K., Boniface, C. T., Lawrence, Y., Pande, N. T., Davies, M. A., Herlyn, M., Muranen, T., Zervantonakis, I. K., von Euw, E., Schultz, A., Kumar, S. V., Korkut, A., Spellman, P. T., ... Liang, H. (2020). Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines. Cancer cell, 38(6), 829-843.e4. https://doi.org/10.1016/j.ccell.2020.10.008

Zhao, W, Li, J, Chen, MJM, Luo, Y, Ju, Z, Nesser, NK, Johnson-Camacho, K, Boniface, CT, Lawrence, Y, Pande, NT, Davies, MA, Herlyn, M, Muranen, T, Zervantonakis, IK, von Euw, E, Schultz, A, Kumar, SV, Korkut, A, Spellman, PT, Akbani, R, Slamon, DJ, Gray, JW, Brugge, JS, Lu, Y, Mills, GB & Liang, H 2020, 'Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines', Cancer cell, vol. 38, no. 6, pp. 829-843.e4. https://doi.org/10.1016/j.ccell.2020.10.008

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title = "Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines",

abstract = "Zhao et al. profile the protein responses of a large collection of cancer cell lines to drug perturbations using the RPPA platform and build a systematic protein-drug connectivity map. The integration of perturbed protein responses provides better prediction of drug sensitivity and insights into drug-resistance mechanisms and combination therapies.",

keywords = "biomarker, cancer signaling pathway, drug response, protein array",

author = "Wei Zhao and Jun Li and Chen, {Mei Ju M.} and Yikai Luo and Zhenlin Ju and Nesser, {Nicole K.} and Katie Johnson-Camacho and Boniface, {Christopher T.} and Yancey Lawrence and Pande, {Nupur T.} and Davies, {Michael A.} and Meenhard Herlyn and Taru Muranen and Zervantonakis, {Ioannis K.} and {von Euw}, Erika and Andre Schultz and Kumar, {Shwetha V.} and Anil Korkut and Spellman, {Paul T.} and Rehan Akbani and Slamon, {Dennis J.} and Gray, {Joe W.} and Brugge, {Joan S.} and Yiling Lu and Mills, {Gordon B.} and Han Liang",

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year = "2020",

month = dec,

day = "14",

doi = "10.1016/j.ccell.2020.10.008",

language = "English (US)",

volume = "38",

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T1 - Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

AU - Zhao, Wei

AU - Li, Jun

AU - Chen, Mei Ju M.

AU - Luo, Yikai

AU - Ju, Zhenlin

AU - Nesser, Nicole K.

AU - Johnson-Camacho, Katie

AU - Boniface, Christopher T.

AU - Lawrence, Yancey

AU - Pande, Nupur T.

AU - Davies, Michael A.

AU - Herlyn, Meenhard

AU - Muranen, Taru

AU - Zervantonakis, Ioannis K.

AU - von Euw, Erika

AU - Schultz, Andre

AU - Kumar, Shwetha V.

AU - Korkut, Anil

AU - Spellman, Paul T.

AU - Akbani, Rehan

AU - Slamon, Dennis J.

AU - Gray, Joe W.

AU - Brugge, Joan S.

AU - Lu, Yiling

AU - Mills, Gordon B.

AU - Liang, Han

PY - 2020/12/14

Y1 - 2020/12/14

N2 - Zhao et al. profile the protein responses of a large collection of cancer cell lines to drug perturbations using the RPPA platform and build a systematic protein-drug connectivity map. The integration of perturbed protein responses provides better prediction of drug sensitivity and insights into drug-resistance mechanisms and combination therapies.

AB - Zhao et al. profile the protein responses of a large collection of cancer cell lines to drug perturbations using the RPPA platform and build a systematic protein-drug connectivity map. The integration of perturbed protein responses provides better prediction of drug sensitivity and insights into drug-resistance mechanisms and combination therapies.

KW - biomarker

KW - cancer signaling pathway

KW - drug response

KW - protein array

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SN - 1535-6108

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SP - 829-843.e4

JO - Cancer cell

JF - Cancer cell

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Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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