Loss of histone acetylation and H3K4 methylation promotes melanocytic malignant transformation

Ayush T. Raman; Kunal Rai

doi:10.1080/23723556.2017.1359229

Loss of histone acetylation and H3K4 methylation promotes melanocytic malignant transformation

Ayush T. Raman, Kunal Rai

Genomic Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Epigenetic mechanisms play essential roles in biological processes such as cell maintenance, differentiation, proliferation and apoptosis. A recent report from our laboratory showed that the loss of histone acetylation and H3K4 (Histone H3 Lysine 4) methylation in the proximal regions of cancer regulatory genes promote tumorigenesis.

Original language	English (US)
Article number	e1359229
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2017.1359229
State	Published - May 4 2018

Keywords

Benign
chromatin states
epigenome
histone modifications
malignant
melanoma
nevi

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2017.1359229

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title = "Loss of histone acetylation and H3K4 methylation promotes melanocytic malignant transformation",

abstract = "Epigenetic mechanisms play essential roles in biological processes such as cell maintenance, differentiation, proliferation and apoptosis. A recent report from our laboratory showed that the loss of histone acetylation and H3K4 (Histone H3 Lysine 4) methylation in the proximal regions of cancer regulatory genes promote tumorigenesis.",

keywords = "Benign, chromatin states, epigenome, histone modifications, malignant, melanoma, nevi",

author = "Raman, {Ayush T.} and Kunal Rai",

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year = "2018",

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AU - Rai, Kunal

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AB - Epigenetic mechanisms play essential roles in biological processes such as cell maintenance, differentiation, proliferation and apoptosis. A recent report from our laboratory showed that the loss of histone acetylation and H3K4 (Histone H3 Lysine 4) methylation in the proximal regions of cancer regulatory genes promote tumorigenesis.

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KW - epigenome

KW - histone modifications

KW - malignant

KW - melanoma

KW - nevi

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Loss of histone acetylation and H3K4 methylation promotes melanocytic malignant transformation

Abstract

Keywords

ASJC Scopus subject areas

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