Mammalian DNA Methyltransferases: A Structural Perspective

Xiaodong Cheng; Robert M. Blumenthal

doi:10.1016/j.str.2008.01.004

Mammalian DNA Methyltransferases: A Structural Perspective

Xiaodong Cheng, Robert M. Blumenthal

Research output: Contribution to journal › Review article › peer-review

326 Scopus citations

Abstract

The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been recognized to play a major role in controlling gene expression, among other functions. Given their importance, it is surprising how many basic questions remain to be answered about the proteins responsible for this methylation and for coordination with the parallel chromatin-marking system that operates at the level of histone modification. This article reviews recent studies on, and discusses the resulting biochemical and structural insights into, the DNA nucleotide methyltransferase (Dnmt) proteins 1, 3a, 3a2, 3b, and 3L.

Original language	English (US)
Pages (from-to)	341-350
Number of pages	10
Journal	Structure
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.str.2008.01.004
State	Published - Mar 11 2008
Externally published	Yes

Keywords

DNA
PROTEINS

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2008.01.004

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title = "Mammalian DNA Methyltransferases: A Structural Perspective",

abstract = "The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been recognized to play a major role in controlling gene expression, among other functions. Given their importance, it is surprising how many basic questions remain to be answered about the proteins responsible for this methylation and for coordination with the parallel chromatin-marking system that operates at the level of histone modification. This article reviews recent studies on, and discusses the resulting biochemical and structural insights into, the DNA nucleotide methyltransferase (Dnmt) proteins 1, 3a, 3a2, 3b, and 3L.",

keywords = "DNA, PROTEINS",

author = "Xiaodong Cheng and Blumenthal, {Robert M.}",

note = "Funding Information: We thank most warmly our colleagues (Steen K.T. Ooi, Timothy H. Bestor, Emily Bernstein, C. David Allis, Renata Z. Jurkowska, and Albert Jeltsch) and coworkers (Da Jia, Zhe Yang, Keqin Li, Chen Qiu, Xing Zhang, and John R. Horton) whose hard work was responsible for much of the DNA methyltransferase work cited in this review. Work in the authors' laboratories is supported in part by grants (National Institutes of Health GM049245 and GM068680 to X.C.; National Science Foundation 0516692 to R.M.B.) and by the Georgia Research Alliance (to X.C.). ",

year = "2008",

month = mar,

day = "11",

doi = "10.1016/j.str.2008.01.004",

language = "English (US)",

volume = "16",

pages = "341--350",

journal = "Structure",

issn = "0969-2126",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Mammalian DNA Methyltransferases

T2 - A Structural Perspective

AU - Cheng, Xiaodong

AU - Blumenthal, Robert M.

N1 - Funding Information: We thank most warmly our colleagues (Steen K.T. Ooi, Timothy H. Bestor, Emily Bernstein, C. David Allis, Renata Z. Jurkowska, and Albert Jeltsch) and coworkers (Da Jia, Zhe Yang, Keqin Li, Chen Qiu, Xing Zhang, and John R. Horton) whose hard work was responsible for much of the DNA methyltransferase work cited in this review. Work in the authors' laboratories is supported in part by grants (National Institutes of Health GM049245 and GM068680 to X.C.; National Science Foundation 0516692 to R.M.B.) and by the Georgia Research Alliance (to X.C.).

PY - 2008/3/11

Y1 - 2008/3/11

N2 - The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been recognized to play a major role in controlling gene expression, among other functions. Given their importance, it is surprising how many basic questions remain to be answered about the proteins responsible for this methylation and for coordination with the parallel chromatin-marking system that operates at the level of histone modification. This article reviews recent studies on, and discusses the resulting biochemical and structural insights into, the DNA nucleotide methyltransferase (Dnmt) proteins 1, 3a, 3a2, 3b, and 3L.

AB - The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been recognized to play a major role in controlling gene expression, among other functions. Given their importance, it is surprising how many basic questions remain to be answered about the proteins responsible for this methylation and for coordination with the parallel chromatin-marking system that operates at the level of histone modification. This article reviews recent studies on, and discusses the resulting biochemical and structural insights into, the DNA nucleotide methyltransferase (Dnmt) proteins 1, 3a, 3a2, 3b, and 3L.

KW - DNA

KW - PROTEINS

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U2 - 10.1016/j.str.2008.01.004

DO - 10.1016/j.str.2008.01.004

M3 - Review article

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AN - SCOPUS:40049094942

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SP - 341

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JO - Structure

JF - Structure

IS - 3

ER -

Mammalian DNA Methyltransferases: A Structural Perspective

Abstract

Keywords

ASJC Scopus subject areas

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