Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

Medicine & Life Sciences

• N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide 100%
• Cyclin-Dependent Kinases 58%
• B-Cell Chronic Lymphocytic Leukemia 53%
• RNA Polymerase II 14%
• Proteins 11%
• alvocidib 9%
• Roscovitine 9%
• X-Linked Inhibitor of Apoptosis Protein 9%
• RNA 8%
• Oncogene Proteins 6%
• Caspases 6%
• Cell Survival 4%
• Cell Death 4%
• History 4%
• Phosphorylation 4%
• Apoptosis 3%
• In Vitro Techniques 2%
• Therapeutics 1%

Chemistry

• Cyclin Dependent Kinase Inhibitor 80%
• Antiapoptotic 23%
• Protein 20%
• Cell Death 8%
• Cell Viability 8%
• Indicator 7%
• Cleavage 5%