Mechanistic insights into the role of truncating PREX2 mutations in melanoma

Yonathan Lissanu Deribe

doi:10.1080/23723556.2016.1160174

Mechanistic insights into the role of truncating PREX2 mutations in melanoma

Yonathan Lissanu Deribe

Genomic Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to increased PI3K/AKT signaling and enhanced cell proliferation.

Original language	English (US)
Article number	e1160174
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2016.1160174
State	Published - May 3 2016

Keywords

Epigenetics
Melanoma
Mouse models of cancer
PI3K
PREX2
RAC1

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2016.1160174

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title = "Mechanistic insights into the role of truncating PREX2 mutations in melanoma",

abstract = "PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to increased PI3K/AKT signaling and enhanced cell proliferation.",

keywords = "Epigenetics, Melanoma, Mouse models of cancer, PI3K, PREX2, RAC1",

author = "{Lissanu Deribe}, Yonathan",

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AB - PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to increased PI3K/AKT signaling and enhanced cell proliferation.

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KW - RAC1

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Mechanistic insights into the role of truncating PREX2 mutations in melanoma

Abstract

Keywords

ASJC Scopus subject areas

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