Molecular approaches to the diagnosis and treatment of cancer

Albert B. Deisseroth; Hagop Kantarjian; Moshe Talpaz; Richard Champlin; Christopher Reading; Elie G. Hanania; Siqing Fu; Gurvaneet S. Randhawa; Ying Cha; Xiangming Fang; Steven M. Kornblau; Nicoletta Pollicardo; Wei Zhang

doi:10.1002/stem.5530110926

Molecular approaches to the diagnosis and treatment of cancer

Albert B. Deisseroth, Hagop Kantarjian, Moshe Talpaz, Richard Champlin, Christopher Reading, Elie G. Hanania, Siqing Fu, Gurvaneet S. Randhawa, Ying Cha, Xiangming Fang, Steven M. Kornblau, Nicoletta Pollicardo, Wei Zhang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of the bone marrow as a conduit through which to introduce regulatory molecules into the patient. This has involved three developmental phases: 1) learning how to develop genetic modification techniques; 2) learning how to develop in vivo selection techniques for the genetically modified cells; and 3) developing molecular vectors for modification of hematopoietic cells for therapy of cancer. These programs will be summarized in terms of their progress at the conference.

Original language	English (US)
Pages (from-to)	129-130
Number of pages	2
Journal	STEM CELLS
Volume	11
Issue number	3 S
DOIs	https://doi.org/10.1002/stem.5530110926
State	Published - Oct 1993

Keywords

Bone marrow transplantation
Chronic myelogenous leukemia
Genetic therapy

ASJC Scopus subject areas

Molecular Medicine
Developmental Biology
Cell Biology

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10.1002/stem.5530110926

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title = "Molecular approaches to the diagnosis and treatment of cancer",

abstract = "We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of the bone marrow as a conduit through which to introduce regulatory molecules into the patient. This has involved three developmental phases: 1) learning how to develop genetic modification techniques; 2) learning how to develop in vivo selection techniques for the genetically modified cells; and 3) developing molecular vectors for modification of hematopoietic cells for therapy of cancer. These programs will be summarized in terms of their progress at the conference.",

keywords = "Bone marrow transplantation, Chronic myelogenous leukemia, Genetic therapy",

author = "Deisseroth, {Albert B.} and Hagop Kantarjian and Moshe Talpaz and Richard Champlin and Christopher Reading and Hanania, {Elie G.} and Siqing Fu and Randhawa, {Gurvaneet S.} and Ying Cha and Xiangming Fang and Kornblau, {Steven M.} and Nicoletta Pollicardo and Wei Zhang",

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T1 - Molecular approaches to the diagnosis and treatment of cancer

AU - Deisseroth, Albert B.

AU - Kantarjian, Hagop

AU - Talpaz, Moshe

AU - Champlin, Richard

AU - Reading, Christopher

AU - Hanania, Elie G.

AU - Fu, Siqing

AU - Randhawa, Gurvaneet S.

AU - Cha, Ying

AU - Fang, Xiangming

AU - Kornblau, Steven M.

AU - Pollicardo, Nicoletta

AU - Zhang, Wei

PY - 1993/10

Y1 - 1993/10

N2 - We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of the bone marrow as a conduit through which to introduce regulatory molecules into the patient. This has involved three developmental phases: 1) learning how to develop genetic modification techniques; 2) learning how to develop in vivo selection techniques for the genetically modified cells; and 3) developing molecular vectors for modification of hematopoietic cells for therapy of cancer. These programs will be summarized in terms of their progress at the conference.

AB - We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of the bone marrow as a conduit through which to introduce regulatory molecules into the patient. This has involved three developmental phases: 1) learning how to develop genetic modification techniques; 2) learning how to develop in vivo selection techniques for the genetically modified cells; and 3) developing molecular vectors for modification of hematopoietic cells for therapy of cancer. These programs will be summarized in terms of their progress at the conference.

KW - Bone marrow transplantation

KW - Chronic myelogenous leukemia

KW - Genetic therapy

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Molecular approaches to the diagnosis and treatment of cancer

Abstract

Keywords

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