Myeloid/lymphoid neoplasms with FGFR1 rearrangement

Paolo Strati; Guilin Tang; Dzifa Y. Duose; Saradhi Mallampati; Rajyalakshmi Luthra; Keyur P. Patel; Mohammad Hussaini; Abu Sayeef Mirza; Rami S. Komrokji; Stephen Oh; John Mascarenhas; Vesna Najfeld; Vivek Subbiah; Hagop Kantarjian; Guillermo Garcia-Manero; Srdan Verstovsek; Naval Daver

doi:10.1080/10428194.2017.1397663

Myeloid/lymphoid neoplasms with FGFR1 rearrangement

Paolo Strati, Guilin Tang, Dzifa Y. Duose, Saradhi Mallampati, Rajyalakshmi Luthra, Keyur P. Patel, Mohammad Hussaini, Abu Sayeef Mirza, Rami S. Komrokji, Stephen Oh, John Mascarenhas, Vesna Najfeld, Vivek Subbiah, Hagop Kantarjian, Guillermo Garcia-Manero, Srdan Verstovsek, Naval Daver

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Myeloid/lymphoid neoplasms with FGFR1 rearrangement are a rare entity. We present a multicenter experience of 17 patients with FISH-confirmed FGFR1 rearrangement. The clinical presentation at diagnosis included myeloproliferative neoplasm (MPN) in 4 (24%) patients, acute leukemia (AL) in 7 (41%), and concomitant MPN with AL in 6 (35%). The two most frequently observed cytogenetic abnormalities were t(8;13)(p11.2;q12)(partner gene ZMYM2) and t(8;22)(p11.2; q11.2)(BCR). Seventy-eight percent of tested patients had a RUNX1 mutation, of whom all had AL. Overall response rate to frontline therapy was 69%, and 76% of patients subsequently received allogeneic stem cell transplant (ASCT). After a median follow-up of 11 months, median progression-free survival was 15 months and median overall survival was not reached. In conclusion, FGFR1-rearranged hematologic malignancies present with features of MPN and/or AL. FGFR1 and RUNX1 are therapeutic targets for ongoing and future clinical trials.

Original language	English (US)
Pages (from-to)	1672-1676
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	59
Issue number	7
DOIs	https://doi.org/10.1080/10428194.2017.1397663
State	Published - Jul 3 2018

Keywords

FGFR1 rearrangement
Myeloproliferative neoplasm
RUNX1
acute leukemia

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Strati, P., Tang, G., Duose, D. Y., Mallampati, S., Luthra, R., Patel, K. P., Hussaini, M., Mirza, A. S., Komrokji, R. S., Oh, S., Mascarenhas, J., Najfeld, V., Subbiah, V., Kantarjian, H., Garcia-Manero, G., Verstovsek, S., & Daver, N. (2018). Myeloid/lymphoid neoplasms with FGFR1 rearrangement. Leukemia and Lymphoma, 59(7), 1672-1676. https://doi.org/10.1080/10428194.2017.1397663

Strati, P , Tang, G , Duose, DY, Mallampati, S, Luthra, R , Patel, KP, Hussaini, M, Mirza, AS, Komrokji, RS, Oh, S, Mascarenhas, J, Najfeld, V, Subbiah, V, Kantarjian, H , Garcia-Manero, G, Verstovsek, S & Daver, N 2018, 'Myeloid/lymphoid neoplasms with FGFR1 rearrangement', Leukemia and Lymphoma, vol. 59, no. 7, pp. 1672-1676. https://doi.org/10.1080/10428194.2017.1397663

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abstract = "Myeloid/lymphoid neoplasms with FGFR1 rearrangement are a rare entity. We present a multicenter experience of 17 patients with FISH-confirmed FGFR1 rearrangement. The clinical presentation at diagnosis included myeloproliferative neoplasm (MPN) in 4 (24%) patients, acute leukemia (AL) in 7 (41%), and concomitant MPN with AL in 6 (35%). The two most frequently observed cytogenetic abnormalities were t(8;13)(p11.2;q12)(partner gene ZMYM2) and t(8;22)(p11.2; q11.2)(BCR). Seventy-eight percent of tested patients had a RUNX1 mutation, of whom all had AL. Overall response rate to frontline therapy was 69%, and 76% of patients subsequently received allogeneic stem cell transplant (ASCT). After a median follow-up of 11 months, median progression-free survival was 15 months and median overall survival was not reached. In conclusion, FGFR1-rearranged hematologic malignancies present with features of MPN and/or AL. FGFR1 and RUNX1 are therapeutic targets for ongoing and future clinical trials.",

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author = "Paolo Strati and Guilin Tang and Duose, {Dzifa Y.} and Saradhi Mallampati and Rajyalakshmi Luthra and Patel, {Keyur P.} and Mohammad Hussaini and Mirza, {Abu Sayeef} and Komrokji, {Rami S.} and Stephen Oh and John Mascarenhas and Vesna Najfeld and Vivek Subbiah and Hagop Kantarjian and Guillermo Garcia-Manero and Srdan Verstovsek and Naval Daver",

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AU - Strati, Paolo

AU - Tang, Guilin

AU - Duose, Dzifa Y.

AU - Mallampati, Saradhi

AU - Luthra, Rajyalakshmi

AU - Patel, Keyur P.

AU - Hussaini, Mohammad

AU - Mirza, Abu Sayeef

AU - Komrokji, Rami S.

AU - Oh, Stephen

AU - Mascarenhas, John

AU - Najfeld, Vesna

AU - Subbiah, Vivek

AU - Kantarjian, Hagop

AU - Garcia-Manero, Guillermo

AU - Verstovsek, Srdan

AU - Daver, Naval

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Myeloid/lymphoid neoplasms with FGFR1 rearrangement are a rare entity. We present a multicenter experience of 17 patients with FISH-confirmed FGFR1 rearrangement. The clinical presentation at diagnosis included myeloproliferative neoplasm (MPN) in 4 (24%) patients, acute leukemia (AL) in 7 (41%), and concomitant MPN with AL in 6 (35%). The two most frequently observed cytogenetic abnormalities were t(8;13)(p11.2;q12)(partner gene ZMYM2) and t(8;22)(p11.2; q11.2)(BCR). Seventy-eight percent of tested patients had a RUNX1 mutation, of whom all had AL. Overall response rate to frontline therapy was 69%, and 76% of patients subsequently received allogeneic stem cell transplant (ASCT). After a median follow-up of 11 months, median progression-free survival was 15 months and median overall survival was not reached. In conclusion, FGFR1-rearranged hematologic malignancies present with features of MPN and/or AL. FGFR1 and RUNX1 are therapeutic targets for ongoing and future clinical trials.

AB - Myeloid/lymphoid neoplasms with FGFR1 rearrangement are a rare entity. We present a multicenter experience of 17 patients with FISH-confirmed FGFR1 rearrangement. The clinical presentation at diagnosis included myeloproliferative neoplasm (MPN) in 4 (24%) patients, acute leukemia (AL) in 7 (41%), and concomitant MPN with AL in 6 (35%). The two most frequently observed cytogenetic abnormalities were t(8;13)(p11.2;q12)(partner gene ZMYM2) and t(8;22)(p11.2; q11.2)(BCR). Seventy-eight percent of tested patients had a RUNX1 mutation, of whom all had AL. Overall response rate to frontline therapy was 69%, and 76% of patients subsequently received allogeneic stem cell transplant (ASCT). After a median follow-up of 11 months, median progression-free survival was 15 months and median overall survival was not reached. In conclusion, FGFR1-rearranged hematologic malignancies present with features of MPN and/or AL. FGFR1 and RUNX1 are therapeutic targets for ongoing and future clinical trials.

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Myeloid/lymphoid neoplasms with FGFR1 rearrangement

Abstract

Keywords

ASJC Scopus subject areas

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