One form and two functions: MBD of SETDB2 is a protein-interacting domain

Jujun Zhou; Taiping Chen; Xiaodong Cheng

doi:10.1016/j.str.2024.01.009

One form and two functions: MBD of SETDB2 is a protein-interacting domain

Jujun Zhou, Taiping Chen, Xiaodong Cheng

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue of Structure, Mahana et al.¹ present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.

Original language	English (US)
Pages (from-to)	258-260
Number of pages	3
Journal	Structure
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.str.2024.01.009
State	Published - Mar 7 2024

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2024.01.009

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abstract = "In this issue of Structure, Mahana et al.1 present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.",

author = "Jujun Zhou and Taiping Chen and Xiaodong Cheng",

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year = "2024",

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T2 - MBD of SETDB2 is a protein-interacting domain

AU - Zhou, Jujun

AU - Chen, Taiping

AU - Cheng, Xiaodong

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Y1 - 2024/3/7

N2 - In this issue of Structure, Mahana et al.1 present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.

AB - In this issue of Structure, Mahana et al.1 present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.

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DO - 10.1016/j.str.2024.01.009

M3 - Comment/debate

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SP - 258

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JO - Structure

JF - Structure

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One form and two functions: MBD of SETDB2 is a protein-interacting domain

Abstract

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