TY - CHAP
T1 - Overview of basic immunology for clinical investigators
AU - Stephen, Bettzy
AU - Hajjar, Joud
N1 - Publisher Copyright:
© Springer International Publishing AG 2017.
PY - 2017
Y1 - 2017
N2 - Tumor exists as a complex network of structures with an ability to evolve and evade the host immune surveillance mechanism. The immune milieu which includes macrophages, dendritic cells, natural killer cells, neutrophils, mast cells, B cells, and T cells are found in the core, the invasive margin, or the adjacent stromal or lymphoid component of the tumor. The immune infiltrate is heterogeneous and varies within a patient and between patients of the same tumor histology. The location, density, functionality, and the cross talk between the immune cells in the tumor microenvironment influence the nature of immune response, prognosis, and treatment outcomes in cancer patients. Therefore, an understanding of the characteristics of the immune cells and their role in tumor immune surveillance is of paramount importance to identify immune targets and to develop novel immune therapeutics in the war against cancer. In this chapter, we provide an overview of the individual components of the human immune system and the translational relevance of predictive biomarkers.
AB - Tumor exists as a complex network of structures with an ability to evolve and evade the host immune surveillance mechanism. The immune milieu which includes macrophages, dendritic cells, natural killer cells, neutrophils, mast cells, B cells, and T cells are found in the core, the invasive margin, or the adjacent stromal or lymphoid component of the tumor. The immune infiltrate is heterogeneous and varies within a patient and between patients of the same tumor histology. The location, density, functionality, and the cross talk between the immune cells in the tumor microenvironment influence the nature of immune response, prognosis, and treatment outcomes in cancer patients. Therefore, an understanding of the characteristics of the immune cells and their role in tumor immune surveillance is of paramount importance to identify immune targets and to develop novel immune therapeutics in the war against cancer. In this chapter, we provide an overview of the individual components of the human immune system and the translational relevance of predictive biomarkers.
KW - Adaptive
KW - CTLA-4
KW - Immune checkpoints
KW - Innate
KW - PD-1
KW - T cells
KW - Tumor immunotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=85015968438&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-53156-4_1
DO - 10.1007/978-3-319-53156-4_1
M3 - Chapter
C2 - 28321810
AN - SCOPUS:85015968438
T3 - Advances in Experimental Medicine and Biology
SP - 1
EP - 31
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -