TY - JOUR
T1 - Pegylated liposomal doxorubicin treatment in recurrent gynecologic cancer patients with renal dysfunction
AU - Li, Yanfang
AU - Finkel, Kevin W.
AU - Hu, Wei
AU - Fu, Siqing
AU - Liu, Jihong
AU - Coleman, Robert
AU - Kavanagh, John J.
PY - 2007/8
Y1 - 2007/8
N2 - Objectives: A paucity of data exists regarding the efficacy and toxicity of pegylated liposomal doxorubicin (PLD) in cancer patients with chronic kidney disease (CKD). We sought to investigate the toxicity and efficacy of PLD in gynecologic cancer patients with CKD. Methods: The clinical records of all patients with recurrent gynecological cancer and CKD at the University of Texas M.D. Anderson Cancer Center from 08/1999 to 08/2006 were reviewed retrospectively to identify patients who received PLD. Results: Twenty-eight patients were identified, which included 14 with epithelial ovarian cancer, 4 with peritoneal cancer, and 10 with other gynecologic cancers. CKD was defined as a creatinine clearance (CrCl) of < 90 ml/min/1.73 m2 and classified as mild (5 patients), moderate (16 patients), or severe (7 patients) (CrCl 60-89, 30-59, and < 30 ml/min/1.73 m2, respectively). The initial doses of PLD were classified into regular initial dose (40 mg/m2/4 weeks) and lower initial dose (30-35 mg/m2/4 weeks). The median cycle was 4.5 (range 1-17). The incidence of grade 3-4 palmar-plantar erythrodysesthesia, stomatitis, and hematologic toxicity was 11.1% (2/18), 5.6% (1/18), and 16.7% (3/18) among 18 patients with an initial dose of 40 mg/m2/4 weeks, which included 5, 10, and 3 patients with mild, moderate, and severe CKD, respectively. Dose reduction due to toxicities occurred in 33.3% (6/18) patients. In 18 patients with ovarian and peritoneal cancer (all platinum-resistant), the rates of complete response, partial response, stable disease, and progression were 0%, 11.1%, 44.4%, and 44.4%, respectively. Conclusions: Patients with CKD who received PLD therapy at an initial dose of 40 mg/m2/4 weeks may require greater subsequent dose reduction mainly secondary to mucocutaneous and hematologic toxicities. Treatment response in this population with ovarian and peritoneal cancer was similar to that of patients with normal renal function.
AB - Objectives: A paucity of data exists regarding the efficacy and toxicity of pegylated liposomal doxorubicin (PLD) in cancer patients with chronic kidney disease (CKD). We sought to investigate the toxicity and efficacy of PLD in gynecologic cancer patients with CKD. Methods: The clinical records of all patients with recurrent gynecological cancer and CKD at the University of Texas M.D. Anderson Cancer Center from 08/1999 to 08/2006 were reviewed retrospectively to identify patients who received PLD. Results: Twenty-eight patients were identified, which included 14 with epithelial ovarian cancer, 4 with peritoneal cancer, and 10 with other gynecologic cancers. CKD was defined as a creatinine clearance (CrCl) of < 90 ml/min/1.73 m2 and classified as mild (5 patients), moderate (16 patients), or severe (7 patients) (CrCl 60-89, 30-59, and < 30 ml/min/1.73 m2, respectively). The initial doses of PLD were classified into regular initial dose (40 mg/m2/4 weeks) and lower initial dose (30-35 mg/m2/4 weeks). The median cycle was 4.5 (range 1-17). The incidence of grade 3-4 palmar-plantar erythrodysesthesia, stomatitis, and hematologic toxicity was 11.1% (2/18), 5.6% (1/18), and 16.7% (3/18) among 18 patients with an initial dose of 40 mg/m2/4 weeks, which included 5, 10, and 3 patients with mild, moderate, and severe CKD, respectively. Dose reduction due to toxicities occurred in 33.3% (6/18) patients. In 18 patients with ovarian and peritoneal cancer (all platinum-resistant), the rates of complete response, partial response, stable disease, and progression were 0%, 11.1%, 44.4%, and 44.4%, respectively. Conclusions: Patients with CKD who received PLD therapy at an initial dose of 40 mg/m2/4 weeks may require greater subsequent dose reduction mainly secondary to mucocutaneous and hematologic toxicities. Treatment response in this population with ovarian and peritoneal cancer was similar to that of patients with normal renal function.
KW - Chronic kidney disease
KW - Endometrial cancer
KW - Ovarian cancer
KW - Pegylated liposomal doxorubicin
KW - Renal dysfunction
KW - Renal failure
UR - http://www.scopus.com/inward/record.url?scp=34447638919&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447638919&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2007.04.011
DO - 10.1016/j.ygyno.2007.04.011
M3 - Article
C2 - 17512575
AN - SCOPUS:34447638919
SN - 0090-8258
VL - 106
SP - 375
EP - 380
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 2
ER -