TY - JOUR
T1 - Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
AU - Teng, Yun
AU - Ren, Yi
AU - Sayed, Mohammed
AU - Hu, Xin
AU - Lei, Chao
AU - Kumar, Anil
AU - Hutchins, Elizabeth
AU - Mu, Jingyao
AU - Deng, Zhongbin
AU - Luo, Chao
AU - Sundaram, Kumaran
AU - Sriwastva, Mukesh K.
AU - Zhang, Lifeng
AU - Hsieh, Michael
AU - Reiman, Rebecca
AU - Haribabu, Bodduluri
AU - Yan, Jun
AU - Jala, Venkatakrishna Rao
AU - Miller, Donald M.
AU - Van Keuren-Jensen, Kendall
AU - Merchant, Michael L.
AU - McClain, Craig J.
AU - Park, Juw Won
AU - Egilmez, Nejat K.
AU - Zhang, Huang Ge
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/11/14
Y1 - 2018/11/14
N2 - The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN-RNAs or I3A, a ligand for aryl hydrocarbon receptor, are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN-RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease. Teng et al. show that exosome-like nanoparticles (ELNs) from edible plants such as ginger are preferentially taken up by gut bacteria in an ELN lipid-dependent manner. ELN RNAs regulate gut microbiota composition and localization as well as host physiology, notably enhancing gut barrier function to alleviate colitis.
AB - The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN-RNAs or I3A, a ligand for aryl hydrocarbon receptor, are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN-RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease. Teng et al. show that exosome-like nanoparticles (ELNs) from edible plants such as ginger are preferentially taken up by gut bacteria in an ELN lipid-dependent manner. ELN RNAs regulate gut microbiota composition and localization as well as host physiology, notably enhancing gut barrier function to alleviate colitis.
KW - IL-22
KW - LexA
KW - and LGG adherence
KW - ginger exosome-like nanoparticle
KW - gut microbiota composition
KW - lipid targeting
KW - miRNA/mRNA interaction
KW - small RNA
KW - tryptophan metabolites
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U2 - 10.1016/j.chom.2018.10.001
DO - 10.1016/j.chom.2018.10.001
M3 - Article
C2 - 30449315
AN - SCOPUS:85056573910
SN - 1931-3128
VL - 24
SP - 637-652.e8
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 5
ER -