Prevention of biofilm colonization by gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine

Mohamed A. Jamal; Joel S. Rosenblatt; Ray Y. Hachem; Jiang Ying; Egbert Pravinkumar; Joseph L. Nates; Anne Marie P. Chaftari; Issam I. Raad

doi:10.1128/AAC.01959-13

Prevention of biofilm colonization by gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine

Mohamed A. Jamal, Joel S. Rosenblatt, Ray Y. Hachem, Jiang Ying, Egbert Pravinkumar, Joseph L. Nates, Anne Marie P. Chaftari, Issam I. Raad

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Resistant Gram-negative bacteria are increasing central-line-associated bloodstream infection threats. To better combat this, chlorhexidine (CHX) was added to minocycline-rifampin (M/R) catheters. The in vitro antimicrobial activity of CHX-M/R catheters against multidrug resistant, Gram-negative Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia was tested. M/R and CHX-silver sulfadiazine (CHX/ SS) catheters were used as comparators. The novel CHX-M/R catheters were significantly more effective (P<0.0001) than CHX/SS or M/R catheters in preventing biofilm colonization and showed better antimicrobial durability.

Original language	English (US)
Pages (from-to)	1179-1182
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01959-13
State	Published - Feb 2014

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Jamal, M. A., Rosenblatt, J. S., Hachem, R. Y., Ying, J., Pravinkumar, E., Nates, J. L., Chaftari, A. M. P., & Raad, I. I. (2014). Prevention of biofilm colonization by gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine. Antimicrobial agents and chemotherapy, 58(2), 1179-1182. https://doi.org/10.1128/AAC.01959-13

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title = "Prevention of biofilm colonization by gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine",

abstract = "Resistant Gram-negative bacteria are increasing central-line-associated bloodstream infection threats. To better combat this, chlorhexidine (CHX) was added to minocycline-rifampin (M/R) catheters. The in vitro antimicrobial activity of CHX-M/R catheters against multidrug resistant, Gram-negative Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia was tested. M/R and CHX-silver sulfadiazine (CHX/ SS) catheters were used as comparators. The novel CHX-M/R catheters were significantly more effective (P<0.0001) than CHX/SS or M/R catheters in preventing biofilm colonization and showed better antimicrobial durability.",

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AU - Jamal, Mohamed A.

AU - Rosenblatt, Joel S.

AU - Hachem, Ray Y.

AU - Ying, Jiang

AU - Pravinkumar, Egbert

AU - Nates, Joseph L.

AU - Chaftari, Anne Marie P.

AU - Raad, Issam I.

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AB - Resistant Gram-negative bacteria are increasing central-line-associated bloodstream infection threats. To better combat this, chlorhexidine (CHX) was added to minocycline-rifampin (M/R) catheters. The in vitro antimicrobial activity of CHX-M/R catheters against multidrug resistant, Gram-negative Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia was tested. M/R and CHX-silver sulfadiazine (CHX/ SS) catheters were used as comparators. The novel CHX-M/R catheters were significantly more effective (P<0.0001) than CHX/SS or M/R catheters in preventing biofilm colonization and showed better antimicrobial durability.

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Prevention of biofilm colonization by gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine

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