TY - JOUR
T1 - Proceedings from the Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA)
AU - Wei, Alexander Z.
AU - Chen, Lanyi N.
AU - Orloff, Marlana
AU - Ariyan, Charlotte E.
AU - Asgari, Maryam
AU - Barker, Christopher A.
AU - Buchbinder, Elizabeth
AU - Chandra, Sunandana
AU - Couts, Kasey
AU - Frumovitz, Michael M.
AU - Futreal, Andrew
AU - Gershenwald, Jeffrey E.
AU - Hanna, Ehab Y
AU - Izar, Benjamin
AU - LeBlanc, Amy K.
AU - Leitao, Mario M.
AU - Lipson, Evan J.
AU - Liu, David
AU - McCarter, Martin
AU - McQuade, Jennifer Leigh
AU - Najjar, Yana
AU - Rapisuwon, Suthee
AU - Selig, Sara
AU - Shoushtari, Alexander N.
AU - Yeh, Iwei
AU - Schwartz, Gary K.
AU - Guo, Jun
AU - Patel, Sapna Pradyuman
AU - Carvajal, Richard D.
N1 - Publisher Copyright:
© 2023 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.
PY - 2023/11
Y1 - 2023/11
N2 - Mucosal melanoma remains a rare cancer with high mortality and a paucity of therapeutic options. This is due in significant part to its low incidence leading to limited patient access to expert care and downstream clinical/basic science data for research interrogation. Clinical challenges such as delayed and at times inaccurate diagnoses, and lack of consensus tumor staging have added to the suboptimal outcomes for these patients. Clinical trials, while promising, have been difficult to activate and accrue. While individual institutions and investigators have attempted to seek solutions to such problems, international, national, and local partnership may provide the keys to more efficient and innovative paths forward. Furthermore, a mucosal melanoma coalition would provide a potential network for patients and caregivers to seek expert opinion and advice. The Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA) highlighted the current clinical challenges faced by patients, providers, and scientists, identified current and future clinical trial investigations in this rare disease space, and aimed to increase national and international collaboration among the mucosal melanoma community in an effort to improve patient outcomes. The included proceedings highlight the clinical challenges of mucosal melanoma, global clinical trial experience, basic science advances in mucosal melanoma, and future directions, including the creation of shared rare tumor registries and enhanced collaborations.
AB - Mucosal melanoma remains a rare cancer with high mortality and a paucity of therapeutic options. This is due in significant part to its low incidence leading to limited patient access to expert care and downstream clinical/basic science data for research interrogation. Clinical challenges such as delayed and at times inaccurate diagnoses, and lack of consensus tumor staging have added to the suboptimal outcomes for these patients. Clinical trials, while promising, have been difficult to activate and accrue. While individual institutions and investigators have attempted to seek solutions to such problems, international, national, and local partnership may provide the keys to more efficient and innovative paths forward. Furthermore, a mucosal melanoma coalition would provide a potential network for patients and caregivers to seek expert opinion and advice. The Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA) highlighted the current clinical challenges faced by patients, providers, and scientists, identified current and future clinical trial investigations in this rare disease space, and aimed to increase national and international collaboration among the mucosal melanoma community in an effort to improve patient outcomes. The included proceedings highlight the clinical challenges of mucosal melanoma, global clinical trial experience, basic science advances in mucosal melanoma, and future directions, including the creation of shared rare tumor registries and enhanced collaborations.
KW - chemotherapy
KW - immunotherapy
KW - melanoma
KW - mucosal melanoma
KW - neoadjuvant
UR - http://www.scopus.com/inward/record.url?scp=85173508928&partnerID=8YFLogxK
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U2 - 10.1111/pcmr.13139
DO - 10.1111/pcmr.13139
M3 - Article
C2 - 37804122
AN - SCOPUS:85173508928
SN - 1755-1471
VL - 36
SP - 542
EP - 556
JO - Pigment Cell and Melanoma Research
JF - Pigment Cell and Melanoma Research
IS - 6
ER -