TY - JOUR
T1 - RAD18 lives a double life
T2 - Its implication in DNA double-strand break repair
AU - Ting, Liu
AU - Jun, Huang
AU - Junjie, Chen
N1 - Funding Information:
We apologize to those colleagues whose work has not been cited due to space limitation. Ting would like to thank Gargi Ghosal, Maude Veech and Diane Hackett for proofreading. This work was supported in part by grants from Startup Fund (Life Sciences Institute, ZJU to J.H.), the Fundamental Research Funds for the Central Universities (to J.H.) and from the National Institutes of Health (to J.C.). J.C is also a recipient of an Era of Hope Scholar award from the Department of Defense (W81XWH-05-1-0470) and a member of M.D. Anderson Cancer Center (CA016672).
PY - 2010/12/10
Y1 - 2010/12/10
N2 - Maintenance of genome stability depends on efficient and accurate repair of DNA lesions. Failure to properly repair damaged DNA can cause cell death, mutations and chromosomal instability, which eventually lead to tumorigenesis. The E3 ligase RAD18 is well-known for its function in DNA damage bypass and post-replication repair (PRR) in yeast and vertebrates via its ability to facilitate PCNA mono-ubiquitination at stalled replication forks. However, emerging evidence has also indicated that RAD18 plays an important role in homologous recombination (HR) in mammalian cells, which is an error-free DNA repair pathway that mediates the repair of double-strand breaks (DSBs). Here, we review how RAD18 carries out these distinct functions in response to different types of DNA lesions.
AB - Maintenance of genome stability depends on efficient and accurate repair of DNA lesions. Failure to properly repair damaged DNA can cause cell death, mutations and chromosomal instability, which eventually lead to tumorigenesis. The E3 ligase RAD18 is well-known for its function in DNA damage bypass and post-replication repair (PRR) in yeast and vertebrates via its ability to facilitate PCNA mono-ubiquitination at stalled replication forks. However, emerging evidence has also indicated that RAD18 plays an important role in homologous recombination (HR) in mammalian cells, which is an error-free DNA repair pathway that mediates the repair of double-strand breaks (DSBs). Here, we review how RAD18 carries out these distinct functions in response to different types of DNA lesions.
KW - Checkpoint
KW - Homologous recombination (HR)
KW - Post-replication repair (PRR)
KW - RAD18
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U2 - 10.1016/j.dnarep.2010.09.016
DO - 10.1016/j.dnarep.2010.09.016
M3 - Review article
C2 - 20971043
AN - SCOPUS:78649451521
SN - 1568-7864
VL - 9
SP - 1241
EP - 1248
JO - DNA Repair
JF - DNA Repair
IS - 12
ER -