TY - JOUR
T1 - Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages
AU - Emile, Jean François
AU - Abla, Oussama
AU - Fraitag, Sylvie
AU - Horne, Annacarin
AU - Haroche, Julien
AU - Donadieu, Jean
AU - Requena-Caballero, Luis
AU - Jordan, Michael B.
AU - Abdel-Wahab, Omar
AU - Allen, Carl E.
AU - Charlotte, Frédéric
AU - Diamond, Eli L.
AU - Egeler, R. Maarten
AU - Fischer, Alain
AU - Herrera, Juana Gil
AU - Henter, Jan Inge
AU - Janku, Filip
AU - Merad, Miriam
AU - Picarsic, Jennifer
AU - Rodriguez-Galindo, Carlos
AU - Rollins, Barret J.
AU - Tazi, Abdellatif
AU - Vassallo, Robert
AU - Weiss, Lawrence M.
AU - Histiocyte Society, Society
N1 - Funding Information:
J.-F.E. received honoraria from Roche and GlaxoSmithKline (GSK). J.H. received grants from Roche. C.E.A. was an unpaid consultant to Novimmune. J.G.H. received grants from Fondo de Investigacion Sanitaria (FIS). R.V. received grants from GSK. L.M.W. received fees from BioTheranostics and Genentech. The remaining authors declare no competing financial interests.
Publisher Copyright:
© 2016 by The American Society of Hematology.
PY - 2016/6/2
Y1 - 2016/6/2
N2 - The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.
AB - The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.
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U2 - 10.1182/blood-2016-01-690636
DO - 10.1182/blood-2016-01-690636
M3 - Review article
C2 - 26966089
AN - SCOPUS:84971328245
SN - 0006-4971
VL - 127
SP - 2672
EP - 2681
JO - Blood
JF - Blood
IS - 22
ER -