RIF1 counteracts BRCA1-mediated end resection during DNA repair

Lin Feng; Ka Wing Fong; Jiadong Wang; Wenqi Wang; Junjie Chen

doi:10.1074/jbc.M113.457440

RIF1 counteracts BRCA1-mediated end resection during DNA repair

Lin Feng, Ka Wing Fong, Jiadong Wang, Wenqi Wang, Junjie Chen

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

Background: 53BP1 counteracts BRCA1 in DNA repair. Results: RIF1 acts downstream of 53BP1 and counteracts BRCA1 in DNA end resection. It also has a 53BP1-independent role in regulating BLM chromatin association. Conclusion: RIF1 is the major downstream effector of 53BP1. Significance: These results reveal that RIF1 antagonizes BRCA1, functions in DNA end protection, and prevents homologous recombination repair.

Original language	English (US)
Pages (from-to)	11135-11143
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.457440
State	Published - Apr 19 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "RIF1 counteracts BRCA1-mediated end resection during DNA repair",

abstract = "Background: 53BP1 counteracts BRCA1 in DNA repair. Results: RIF1 acts downstream of 53BP1 and counteracts BRCA1 in DNA end resection. It also has a 53BP1-independent role in regulating BLM chromatin association. Conclusion: RIF1 is the major downstream effector of 53BP1. Significance: These results reveal that RIF1 antagonizes BRCA1, functions in DNA end protection, and prevents homologous recombination repair.",

author = "Lin Feng and Fong, {Ka Wing} and Jiadong Wang and Wenqi Wang and Junjie Chen",

year = "2013",

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T1 - RIF1 counteracts BRCA1-mediated end resection during DNA repair

AU - Feng, Lin

AU - Fong, Ka Wing

AU - Wang, Jiadong

AU - Wang, Wenqi

AU - Chen, Junjie

PY - 2013/4/19

Y1 - 2013/4/19

N2 - Background: 53BP1 counteracts BRCA1 in DNA repair. Results: RIF1 acts downstream of 53BP1 and counteracts BRCA1 in DNA end resection. It also has a 53BP1-independent role in regulating BLM chromatin association. Conclusion: RIF1 is the major downstream effector of 53BP1. Significance: These results reveal that RIF1 antagonizes BRCA1, functions in DNA end protection, and prevents homologous recombination repair.

AB - Background: 53BP1 counteracts BRCA1 in DNA repair. Results: RIF1 acts downstream of 53BP1 and counteracts BRCA1 in DNA end resection. It also has a 53BP1-independent role in regulating BLM chromatin association. Conclusion: RIF1 is the major downstream effector of 53BP1. Significance: These results reveal that RIF1 antagonizes BRCA1, functions in DNA end protection, and prevents homologous recombination repair.

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JF - Journal of Biological Chemistry

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RIF1 counteracts BRCA1-mediated end resection during DNA repair

Abstract

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