Sex-dimorphic association of plasma fatty acids with cardiovascular fitness in young and middle-aged general adults: Subsamples from NHANES 2003–2004

Pei Ling Tsou, Chang Jiun Wu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

To explore the potential association of plasma fatty acids (FAs) and cardiovascular fitness level (CVFL), data of 449 subjects from 2003–2004 National Health and Nutrition Examination Survey (NHANES) were analyzed. Among these 249 men and 200 women, aged 20–50 years (33.4 ± 8.4 year, mean ± Standard Deviation), 79 low, 166 moderate and 204 high CVFL were categorized by age-and gender-specific percentile, respectively. Twenty-four fatty acids were quantified from fasting plasma. Higher levels of 2 very long-chain saturated FAs (VLSFAs): Arachidic acid (AR1, C20:0) and Docosanoic acid (DA1, C22:0) as well as 2 n-6 polyunsaturated FAs (PUFAs): Arachidonic acid (AA, C20:4n-6) and Docosatetraenoic acid (DTA, C22:4n-6) were observed in the subjects with low CVFL. Notably this association exists only in men. Estimated maximal oxygen consumption (VO2max), the marker for cardiorespiratory fitness, was used for further regression analysis. After the adjustment of potential confounding factors (age, smoking, hypertension status, body mass index (BMI), insulin resistance status, and C-reactive protein (CRP), AA was the only FA correlated with low VO2max in women; while in men AR1, DA1, AA, and DTA remain negatively associated with VO2max. This preliminary analysis suggests a sex-dimorphic relationship between these plasma VLSFAs and n-6 PUFAs with CVFL and merits further investigation.

Original languageEnglish (US)
Article number1558
JournalNutrients
Volume10
Issue number10
DOIs
StatePublished - Oct 20 2018

Keywords

  • Cardiovascular disease
  • Cardiovascular fitness
  • Fatty acids
  • Omega-6 polyunsaturated fatty acid
  • Plasma
  • Very long chain saturated fatty acid

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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