TY - JOUR
T1 - Sister chromatid tension and the spindle assembly checkpoint
AU - Nezi, Luigi
AU - Musacchio, Andrea
N1 - Funding Information:
Roberta, Edoardo and AM welcome Tommaso, born on December 14, 2008. We apologize to all those authors whose work could not be cited owing to space restrains. Work in the Musacchio laboratory is generously funded by the Association for International Cancer Resarch (AICR), the Telethon Foundation , the European Commission's FP6 program contracts 3D-Repertoire and Mitocheck and the FP7 European Research Council grant KINCON , the Italian Association for Cancer Research (AIRC), the Fondo di Investimento per la Ricerca di Base (FIRB), the Italian Ministry of Health , and the Cariplo Foundation .
PY - 2009/12
Y1 - 2009/12
N2 - The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.
AB - The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.
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U2 - 10.1016/j.ceb.2009.09.007
DO - 10.1016/j.ceb.2009.09.007
M3 - Review article
C2 - 19846287
AN - SCOPUS:70549107618
SN - 0955-0674
VL - 21
SP - 785
EP - 795
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -