TY - JOUR
T1 - Sleep quality and its association with fatigue, symptom burden, and mood in patients with advanced cancer in a clinic for early-phase oncology clinical trials
AU - George, Goldy C.
AU - Iwuanyanwu, Eucharia C.
AU - Anderson, Karen O.
AU - Yusuf, Alizeh
AU - Zinner, Ralph G.
AU - Piha-Paul, Sarina A.
AU - Tsimberidou, Apostolia M.
AU - Naing, Aung
AU - Fu, Siqing
AU - Janku, Filip
AU - Subbiah, Vivek
AU - Cleeland, Charles S.
AU - Mendoza, Tito R.
AU - Hong, David S.
N1 - Publisher Copyright:
© 2016 American Cancer Society
PY - 2016/11/15
Y1 - 2016/11/15
N2 - BACKGROUND: Limited data exist about sleep quality for patients with advanced cancer in phase 1 clinical trials. Poor sleep quality is often not captured as an adverse event, and its association with fatigue, one of the most frequently reported adverse events, is not documented routinely. This article describes sleep quality and its relation with fatigue, symptom burden, and mood in patients recruited from an early-phase clinic for targeted therapy. METHODS: Sleep, fatigue, symptom burden, and mood were assessed with the Pittsburgh Sleep Quality Index (PSQI), the Brief Fatigue Inventory, the MD Anderson Symptom Inventory (MDASI), and the Brief Profile of Mood States, respectively; the Eastern Cooperative Oncology Group (ECOG) performance status (PS) was determined from medical records. RESULTS: The sample (n = 256) was 51.2% female, 90% had an ECOG PS of 0 or 1, and the mean age was 58 ± 0.8 years. Poor sleepers (global PSQI score > 5) constituted 64% of the sample. In separate multiple regression models, poor sleepers had higher levels of fatigue (P <.001), symptom burden (P <.001), and overall mood disturbance (P <.001) than good sleepers. Also, compared with good sleepers, poor sleepers had greater fatigue-related and symptom-related interference with daily activities (all P values <.001). The MDASI disturbed-sleep item correlated well with the global PSQI score (Pearson's r = 0.679, P <.001), and this suggests its usefulness as a patient-reported outcome screener of sleep quality in early-phase clinical trials clinics. CONCLUSIONS: Poor sleep quality was a significant problem in the current study and was associated with greater fatigue, symptom burden, and mood disturbance. Sleep quality should be routinely assessed in patients with advanced cancer who are participating in early-phase clinical trials. Cancer 2016;122:3401–3409.
AB - BACKGROUND: Limited data exist about sleep quality for patients with advanced cancer in phase 1 clinical trials. Poor sleep quality is often not captured as an adverse event, and its association with fatigue, one of the most frequently reported adverse events, is not documented routinely. This article describes sleep quality and its relation with fatigue, symptom burden, and mood in patients recruited from an early-phase clinic for targeted therapy. METHODS: Sleep, fatigue, symptom burden, and mood were assessed with the Pittsburgh Sleep Quality Index (PSQI), the Brief Fatigue Inventory, the MD Anderson Symptom Inventory (MDASI), and the Brief Profile of Mood States, respectively; the Eastern Cooperative Oncology Group (ECOG) performance status (PS) was determined from medical records. RESULTS: The sample (n = 256) was 51.2% female, 90% had an ECOG PS of 0 or 1, and the mean age was 58 ± 0.8 years. Poor sleepers (global PSQI score > 5) constituted 64% of the sample. In separate multiple regression models, poor sleepers had higher levels of fatigue (P <.001), symptom burden (P <.001), and overall mood disturbance (P <.001) than good sleepers. Also, compared with good sleepers, poor sleepers had greater fatigue-related and symptom-related interference with daily activities (all P values <.001). The MDASI disturbed-sleep item correlated well with the global PSQI score (Pearson's r = 0.679, P <.001), and this suggests its usefulness as a patient-reported outcome screener of sleep quality in early-phase clinical trials clinics. CONCLUSIONS: Poor sleep quality was a significant problem in the current study and was associated with greater fatigue, symptom burden, and mood disturbance. Sleep quality should be routinely assessed in patients with advanced cancer who are participating in early-phase clinical trials. Cancer 2016;122:3401–3409.
KW - clinical trials
KW - fatigue
KW - mood
KW - patients with advanced cancer
KW - sleep quality
KW - symptom burden
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U2 - 10.1002/cncr.30182
DO - 10.1002/cncr.30182
M3 - Article
C2 - 27412379
AN - SCOPUS:84991628688
SN - 0008-543X
VL - 122
SP - 3401
EP - 3409
JO - Cancer
JF - Cancer
IS - 21
ER -