Abstract
The stability of cisatracurium besylate was studied. Cisatracurium (as besylate) 2 mg/mL in 5- and 10-mL unopened vials and 10 mg/mL in 20-mL unopened vials, as well as 3 mL of solution from additional 2-mg/mL vials, repackaged in 3-mL sealed plastic syringes, was stored at 4 and 23 °C in the dark and in normal fluorescent room light. Admixtures of cisatracurium (as besylate) 0.1, 2, or 5 mg/mL in polyvinyl chloride (PVC) minibags of 5% dextrose injection or 0.9% sodium chloride injection were stored at 4 and 23 °C in normal fluorescent room light. Triplicate samples for each storage condition were taken initially and at 1, 3, 5, 7, 14, 21, and 30 days; samples from vials were also removed at 45 and 90 days. Solutions were stored in sterile vials at -70 °C and then thawed at room temperature before analysis of chemical stability by high-performance liquid chromatography. Physical stability was assessed as well. Cisatracurium besylate was physically stable in all samples throughout the study. Cisatracurium (as besylate) 2 mg/mL exhibited drug losses at 23 °C in vials at 45 days and in syringes at 30 days. Cisatracurium (as besylate) 0.1, 2, and 5 mg/mL in 5% dextrose injection and in 0.9% sodium chloride injection was stable for at least 30 days at 4 °C, but substantial drug losses occurred at 23 °C. Admixtures prepared with cisatracurium (as besylate) 0.1 mg/mL and with 5% dextrose injection exhibited the greatest losses. Cisatracurium besylate was stable in most samples for at least 30 days at 4 and 23 °C; admixtures containing cisatracurium (as besylate) 0.1 or 2 mg/mL exhibited substantial drug loss at 23 °C.
Original language | English (US) |
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Pages (from-to) | 1037-1041 |
Number of pages | 5 |
Journal | American Journal of Health-System Pharmacy |
Volume | 55 |
Issue number | 10 |
DOIs | |
State | Published - May 15 1998 |
Externally published | Yes |
Keywords
- Additives
- Cisatracurium besylate
- Concentration
- Containers
- Dextrose
- Diluents
- Incompatibilities
- Injecti ons
- Photodecomposition
- Polyvinyl chloride
- Skeletal muscle relaxants
- Sodium chloride
- Stability
- Storage
- Syringes
- Temperature
- Vials
ASJC Scopus subject areas
- Pharmacology
- Health Policy