Synthesis and characterization of highly lipophilic antitumor platinum(II) complexes

Abdul R. Khokhar; Quanyun Xu; Salaam Al-Baker

doi:10.1080/00958979109409737

Synthesis and characterization of highly lipophilic antitumor platinum(II) complexes

Abdul R. Khokhar, Quanyun Xu, Salaam Al-Baker

Institute for Applied Cancer Science (IACS)

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A series of highly lipophilic platinum(II) complexes of the type [Pt(OCOR)₂(A)] or [Pt(OCOR)₂(A')₂], where R = a highly branched or long chain alkyl group of 4–13 carbons, A =l R, 2R-diaminocycIo- hexane, cis-I, 2-diaminocyclohexane, 1, 1-bis(aminomethyl)cyclohexane or ethylenediamine and A' = neopentylamine or cyclopentylamine, has been synthesized. These complexes have been characterized by elemental analysis and various spectroscopic techniques [IR, ^l3C and ¹⁹⁵Pt NMR].

Original language	English (US)
Pages (from-to)	77-82
Number of pages	6
Journal	Journal of Coordination Chemistry
Volume	24
Issue number	1
DOIs	https://doi.org/10.1080/00958979109409737
State	Published - Jul 1 1991

Keywords

Platinum
amine
carboxylate
diamine
lipophilic

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Materials Chemistry

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10.1080/00958979109409737

Cite this

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title = "Synthesis and characterization of highly lipophilic antitumor platinum(II) complexes",

abstract = "A series of highly lipophilic platinum(II) complexes of the type [Pt(OCOR)2(A)] or [Pt(OCOR)2(A')2], where R = a highly branched or long chain alkyl group of 4–13 carbons, A =l R, 2R-diaminocycIo- hexane, cis-I, 2-diaminocyclohexane, 1, 1-bis(aminomethyl)cyclohexane or ethylenediamine and A' = neopentylamine or cyclopentylamine, has been synthesized. These complexes have been characterized by elemental analysis and various spectroscopic techniques [IR, l3C and 195Pt NMR].",

keywords = "Platinum, amine, carboxylate, diamine, lipophilic",

author = "Khokhar, {Abdul R.} and Quanyun Xu and Salaam Al-Baker",

note = "Funding Information: This work was supported by Grant CA41581 from the National Cancer Institute. We are grateful to Michael Costigan for technical assistance.",

year = "1991",

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doi = "10.1080/00958979109409737",

language = "English (US)",

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journal = "Journal of Coordination Chemistry",

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T1 - Synthesis and characterization of highly lipophilic antitumor platinum(II) complexes

AU - Khokhar, Abdul R.

AU - Xu, Quanyun

AU - Al-Baker, Salaam

N1 - Funding Information: This work was supported by Grant CA41581 from the National Cancer Institute. We are grateful to Michael Costigan for technical assistance.

PY - 1991/7/1

Y1 - 1991/7/1

N2 - A series of highly lipophilic platinum(II) complexes of the type [Pt(OCOR)2(A)] or [Pt(OCOR)2(A')2], where R = a highly branched or long chain alkyl group of 4–13 carbons, A =l R, 2R-diaminocycIo- hexane, cis-I, 2-diaminocyclohexane, 1, 1-bis(aminomethyl)cyclohexane or ethylenediamine and A' = neopentylamine or cyclopentylamine, has been synthesized. These complexes have been characterized by elemental analysis and various spectroscopic techniques [IR, l3C and 195Pt NMR].

AB - A series of highly lipophilic platinum(II) complexes of the type [Pt(OCOR)2(A)] or [Pt(OCOR)2(A')2], where R = a highly branched or long chain alkyl group of 4–13 carbons, A =l R, 2R-diaminocycIo- hexane, cis-I, 2-diaminocyclohexane, 1, 1-bis(aminomethyl)cyclohexane or ethylenediamine and A' = neopentylamine or cyclopentylamine, has been synthesized. These complexes have been characterized by elemental analysis and various spectroscopic techniques [IR, l3C and 195Pt NMR].

KW - Platinum

KW - amine

KW - carboxylate

KW - diamine

KW - lipophilic

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Synthesis and characterization of highly lipophilic antitumor platinum(II) complexes

Abstract

Keywords

ASJC Scopus subject areas

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