Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes

Abdul R. Khokhar; Quanyun Xu; Robert A. Newman; Yuichiro Kido; Zahid H. Siddik

doi:10.1016/0162-0134(92)80046-X

Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes

Abdul R. Khokhar, Quanyun Xu, Robert A. Newman, Yuichiro Kido, Zahid H. Siddik

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and ¹H and ¹⁹⁵Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.

Original language	English (US)
Pages (from-to)	211-219
Number of pages	9
Journal	Journal of Inorganic Biochemistry
Volume	45
Issue number	3
DOIs	https://doi.org/10.1016/0162-0134(92)80046-X
State	Published - Feb 15 1992

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

Access to Document

10.1016/0162-0134(92)80046-X

Cite this

@article{dfd0aa80b13a46a38af29a88373c4a86,

title = "Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes",

abstract = "A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.",

author = "Khokhar, {Abdul R.} and Quanyun Xu and Newman, {Robert A.} and Yuichiro Kido and Siddik, {Zahid H.}",

year = "1992",

month = feb,

day = "15",

doi = "10.1016/0162-0134(92)80046-X",

language = "English (US)",

volume = "45",

pages = "211--219",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes

AU - Khokhar, Abdul R.

AU - Xu, Quanyun

AU - Newman, Robert A.

AU - Kido, Yuichiro

AU - Siddik, Zahid H.

PY - 1992/2/15

Y1 - 1992/2/15

N2 - A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.

AB - A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.

UR - http://www.scopus.com/inward/record.url?scp=0026528667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026528667&partnerID=8YFLogxK

U2 - 10.1016/0162-0134(92)80046-X

DO - 10.1016/0162-0134(92)80046-X

M3 - Article

C2 - 1634893

AN - SCOPUS:0026528667

SN - 0162-0134

VL - 45

SP - 211

EP - 219

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 3

ER -

Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this