Targeting the c-Met Kinase

Chad Tang; M. Angelica Cortez; David Hong; James W. Welsh

doi:10.1002/9781118468678.ch34

Targeting the c-Met Kinase

Chad Tang, M. Angelica Cortez, David Hong, James W. Welsh

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The expression of the cell membrane receptor and proto-oncogene c-Met has been linked with numerous aspects of cancer development, among the best characterized of which are the development of metastasis and the development of resistance toward molecularly targeted therapeutics. This chapter covers aspects of c-Met expression in various types of tumors, crosstalk among c-Met and other signaling pathways, the potential roles of c-Met signaling in targeted therapies, the development of treatment resistance, and anti-c-Met therapeutics now in development.

Original language	English (US)
Title of host publication	Targeted Therapy in Translational Cancer Research
Publisher	Wiley-Blackwell
Pages	341-346
Number of pages	6
ISBN (Electronic)	9781118468678
ISBN (Print)	9781118468579
DOIs	https://doi.org/10.1002/9781118468678.ch34
State	Published - Oct 30 2015

Keywords

Antibodies
C-Met signaling
EGFR
Lung cancer
Treatment resistance
Tyrosine kinase inhibitors
VEGF

ASJC Scopus subject areas

General Medicine

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10.1002/9781118468678.ch34

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title = "Targeting the c-Met Kinase",

abstract = "The expression of the cell membrane receptor and proto-oncogene c-Met has been linked with numerous aspects of cancer development, among the best characterized of which are the development of metastasis and the development of resistance toward molecularly targeted therapeutics. This chapter covers aspects of c-Met expression in various types of tumors, crosstalk among c-Met and other signaling pathways, the potential roles of c-Met signaling in targeted therapies, the development of treatment resistance, and anti-c-Met therapeutics now in development.",

keywords = "Antibodies, C-Met signaling, EGFR, Lung cancer, Treatment resistance, Tyrosine kinase inhibitors, VEGF",

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T1 - Targeting the c-Met Kinase

AU - Tang, Chad

AU - Cortez, M. Angelica

AU - Hong, David

AU - Welsh, James W.

PY - 2015/10/30

Y1 - 2015/10/30

N2 - The expression of the cell membrane receptor and proto-oncogene c-Met has been linked with numerous aspects of cancer development, among the best characterized of which are the development of metastasis and the development of resistance toward molecularly targeted therapeutics. This chapter covers aspects of c-Met expression in various types of tumors, crosstalk among c-Met and other signaling pathways, the potential roles of c-Met signaling in targeted therapies, the development of treatment resistance, and anti-c-Met therapeutics now in development.

AB - The expression of the cell membrane receptor and proto-oncogene c-Met has been linked with numerous aspects of cancer development, among the best characterized of which are the development of metastasis and the development of resistance toward molecularly targeted therapeutics. This chapter covers aspects of c-Met expression in various types of tumors, crosstalk among c-Met and other signaling pathways, the potential roles of c-Met signaling in targeted therapies, the development of treatment resistance, and anti-c-Met therapeutics now in development.

KW - Antibodies

KW - C-Met signaling

KW - EGFR

KW - Lung cancer

KW - Treatment resistance

KW - Tyrosine kinase inhibitors

KW - VEGF

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M3 - Chapter

AN - SCOPUS:85015825789

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SP - 341

EP - 346

BT - Targeted Therapy in Translational Cancer Research

PB - Wiley-Blackwell

ER -

Targeting the c-Met Kinase

Abstract

Keywords

ASJC Scopus subject areas

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