Abstract
Interest in the abscopal effect has been rekindled over the past decade with the advent of immunotherapy. Although purportedly elusive, this phenomenon is being increasingly reported. Venturing further using a multimodality approach with an array of systemic agents and unconventional modalities is direly needed. In this perspective, we describe the fundamentals of abscopal responses (ARs), explore combinations with systemic therapies that hold promise in eliciting ARs, and reconnoiter unconventional modalities that may induce ARs. Finally, we scrutinize prospective agents and modalities that exhibit preclinical ability to elicit ARs and discuss prognostic biomarkers, their limitations, and pathways of abscopal resistance for reproducibility.
Original language | English (US) |
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Pages (from-to) | 233-244 |
Number of pages | 12 |
Journal | Med |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Apr 14 2023 |
Keywords
- abscopal
- cancer
- nanoparticle therapy
- radionuclide therapy
- systemic therapy
ASJC Scopus subject areas
- General Medicine