The emerging role of b cells in tumor immunity

Peiling Tsou; Hiroyuki Katayama; Edwin J. Ostrin; Samir M. Hanash

doi:10.1158/0008-5472.CAN-16-0431

The emerging role of b cells in tumor immunity

Peiling Tsou, Hiroyuki Katayama, Edwin J. Ostrin, Samir M. Hanash

Research output: Contribution to journal › Review article › peer-review

233 Scopus citations

Abstract

There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many types of cancers. However, B cells represent a heterogeneous population with functionally distinct subsets, and the balance among subtypes impacts tumor development. Here, we review recent findings related to B cells and to the humoral immune response in cancer and their translational significance. Cancer Res; 76(19); 5597-601.

Original language	English (US)
Pages (from-to)	5591-5601
Number of pages	11
Journal	Cancer Research
Volume	76
Issue number	19
DOIs	https://doi.org/10.1158/0008-5472.CAN-16-0431
State	Published - Oct 1 2016

ASJC Scopus subject areas

Oncology
Cancer Research

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AB - There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many types of cancers. However, B cells represent a heterogeneous population with functionally distinct subsets, and the balance among subtypes impacts tumor development. Here, we review recent findings related to B cells and to the humoral immune response in cancer and their translational significance. Cancer Res; 76(19); 5597-601.

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The emerging role of b cells in tumor immunity

Abstract

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