The INK4α/ARF locus and melanoma

Norman E. Sharpless; Lynda Chin

doi:10.1038/sj.onc.1206461

The INK4α/ARF locus and melanoma

Norman E. Sharpless, Lynda Chin

Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

205 Scopus citations

Abstract

Inactivation of the INK4α/ARF (or CDKN2α) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways through its capacity to encode two distinct gene products, p16^INK4a and p14^ARF. This review highlights the body of evidence supporting a role for both p16^INK4a and p14^ARF in the suppression of melanoma, and speculates as to why this locus is preferentially targeted in this tumor type. In addition, the potential importance of these two pathways in mediating UV-induced melanoma genesis will be addressed via genetic and molecular evidence in the mouse.

Original language	English (US)
Pages (from-to)	3092-3098
Number of pages	7
Journal	Oncogene
Volume	22
Issue number	20
DOIs	https://doi.org/10.1038/sj.onc.1206461
State	Published - May 19 2003

Keywords

Cell cycle
Ultraviolet light
cdk4
cdk6
p19

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/sj.onc.1206461

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abstract = "Inactivation of the INK4α/ARF (or CDKN2α) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways through its capacity to encode two distinct gene products, p16INK4a and p14ARF. This review highlights the body of evidence supporting a role for both p16INK4a and p14ARF in the suppression of melanoma, and speculates as to why this locus is preferentially targeted in this tumor type. In addition, the potential importance of these two pathways in mediating UV-induced melanoma genesis will be addressed via genetic and molecular evidence in the mouse.",

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AU - Sharpless, Norman E.

AU - Chin, Lynda

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N2 - Inactivation of the INK4α/ARF (or CDKN2α) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways through its capacity to encode two distinct gene products, p16INK4a and p14ARF. This review highlights the body of evidence supporting a role for both p16INK4a and p14ARF in the suppression of melanoma, and speculates as to why this locus is preferentially targeted in this tumor type. In addition, the potential importance of these two pathways in mediating UV-induced melanoma genesis will be addressed via genetic and molecular evidence in the mouse.

AB - Inactivation of the INK4α/ARF (or CDKN2α) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways through its capacity to encode two distinct gene products, p16INK4a and p14ARF. This review highlights the body of evidence supporting a role for both p16INK4a and p14ARF in the suppression of melanoma, and speculates as to why this locus is preferentially targeted in this tumor type. In addition, the potential importance of these two pathways in mediating UV-induced melanoma genesis will be addressed via genetic and molecular evidence in the mouse.

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KW - Ultraviolet light

KW - cdk4

KW - cdk6

KW - p19

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The INK4α/ARF locus and melanoma

Abstract

Keywords

ASJC Scopus subject areas

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