TY - JOUR
T1 - The INK4a/ARF tumor suppressor
T2 - One gene-two products-two pathways
AU - Chin, Lynda
AU - Pomerantz, Jason
AU - Depinho, Ronald A.
N1 - Funding Information:
We thank Nicole Schreiber-Agus, Liang Zhu, Richard Pestell, Tal Raveh and Glenn Merlino for critical reading of the manuscript. J. P. is a Howard Hughes Medical Institute Medical Student Research Training Fellow. R. A. D is supported by grants from the NIH (NIH grants R01HD28317, R01EY09300 and R01EY11267), as well as the Irma T. Hirschl Award. We also thank the Albert Einstein Cancer Center for support (core grant P30CA13330).
PY - 1998/8/1
Y1 - 1998/8/1
N2 - Functional inactivation of the retinoblastoma (RB) and p53 pathways appears to be a rite of passage for all cancerous cells and results in disruption of cell-cycle regulation and deactivation of the apoptotic response that normally ensues. The INKa/ARF locus sits at the nexus of these two growth-control pathways, by virtue of its ability to generate two distinct products: the p16(INKa) protein, a cyclin-dependent kinase inhibitor that functions upstream of RB; and the p19(ARF) protein, which blocks MDM2 inhibition of p53 activity. This 'one gene-two products-two pathways' arrangement provides a basis for the prominence of INKa/ARF in tumorgenesis. Copyright (C) 1998 Elsevier Science Ltd.
AB - Functional inactivation of the retinoblastoma (RB) and p53 pathways appears to be a rite of passage for all cancerous cells and results in disruption of cell-cycle regulation and deactivation of the apoptotic response that normally ensues. The INKa/ARF locus sits at the nexus of these two growth-control pathways, by virtue of its ability to generate two distinct products: the p16(INKa) protein, a cyclin-dependent kinase inhibitor that functions upstream of RB; and the p19(ARF) protein, which blocks MDM2 inhibition of p53 activity. This 'one gene-two products-two pathways' arrangement provides a basis for the prominence of INKa/ARF in tumorgenesis. Copyright (C) 1998 Elsevier Science Ltd.
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U2 - 10.1016/S0968-0004(98)01236-5
DO - 10.1016/S0968-0004(98)01236-5
M3 - Review article
C2 - 9757829
AN - SCOPUS:0031710479
SN - 0968-0004
VL - 23
SP - 291
EP - 296
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 8
ER -