The mechanisms of generation, recognition, and erasure of DNA 5-methylcytosine and thymine oxidation

Hideharu Hashimoto; Xing Zhang; Paula M. Vertino; Xiaodong Cheng

doi:10.1074/jbc.R115.656884

The mechanisms of generation, recognition, and erasure of DNA 5-methylcytosine and thymine oxidation

Hideharu Hashimoto, Xing Zhang, Paula M. Vertino, Xiaodong Cheng

Research output: Contribution to journal › Short survey › peer-review

33 Scopus citations

Abstract

One of the most fundamental questions in the control of gene expression in mammals is how the patterns of epigenetic modifications of DNA are generated, recognized, and erased. This includes covalent cytosine methylation of DNA and its associated oxidation states. An array of AdoMet-dependent methyltransferases, Fe(II)- and α-ketoglutarate-dependent dioxygenases, base excision glycosylases, and sequence-specific transcription factors is responsible for changing, maintaining, and interpreting the modification status of specific regions of chromatin. This review focuses on recent developments in characterizing the functional and structural links between the modification status of two DNA bases 5-methylcytosine and thymine (5-methyluracil).

Original language	English (US)
Pages (from-to)	20723-20733
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	290
Issue number	34
DOIs	https://doi.org/10.1074/jbc.R115.656884
State	Published - Aug 21 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "The mechanisms of generation, recognition, and erasure of DNA 5-methylcytosine and thymine oxidation",

abstract = "One of the most fundamental questions in the control of gene expression in mammals is how the patterns of epigenetic modifications of DNA are generated, recognized, and erased. This includes covalent cytosine methylation of DNA and its associated oxidation states. An array of AdoMet-dependent methyltransferases, Fe(II)- and α-ketoglutarate-dependent dioxygenases, base excision glycosylases, and sequence-specific transcription factors is responsible for changing, maintaining, and interpreting the modification status of specific regions of chromatin. This review focuses on recent developments in characterizing the functional and structural links between the modification status of two DNA bases 5-methylcytosine and thymine (5-methyluracil).",

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AU - Hashimoto, Hideharu

AU - Zhang, Xing

AU - Vertino, Paula M.

AU - Cheng, Xiaodong

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AB - One of the most fundamental questions in the control of gene expression in mammals is how the patterns of epigenetic modifications of DNA are generated, recognized, and erased. This includes covalent cytosine methylation of DNA and its associated oxidation states. An array of AdoMet-dependent methyltransferases, Fe(II)- and α-ketoglutarate-dependent dioxygenases, base excision glycosylases, and sequence-specific transcription factors is responsible for changing, maintaining, and interpreting the modification status of specific regions of chromatin. This review focuses on recent developments in characterizing the functional and structural links between the modification status of two DNA bases 5-methylcytosine and thymine (5-methyluracil).

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The mechanisms of generation, recognition, and erasure of DNA 5-methylcytosine and thymine oxidation

Abstract

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