The "Two-Faced" effects of reactive oxygen species and the lipid peroxidation product 4-Hydroxynonenal in the hallmarks of cancer

Stefania Pizzimenti; Cristina Toaldo; Piergiorgio Pettazzoni; Mario U. Dianzani; Giuseppina Barrera

doi:10.3390/cancers2020338

The "Two-Faced" effects of reactive oxygen species and the lipid peroxidation product 4-Hydroxynonenal in the hallmarks of cancer

Stefania Pizzimenti, Cristina Toaldo, Piergiorgio Pettazzoni, Mario U. Dianzani, Giuseppina Barrera

Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer.

Original language	English (US)
Pages (from-to)	338-363
Number of pages	26
Journal	Cancers
Volume	2
Issue number	2
DOIs	https://doi.org/10.3390/cancers2020338
State	Published - Jun 2010

Keywords

4-hydroxynonenal
Carcinogenesis
Hallmarks of cancer
Lipid peroxidation
Oxidative stress
ROS

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers2020338

Cite this

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abstract = "Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the {"}two-faced{"} character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer.",

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AU - Dianzani, Mario U.

AU - Barrera, Giuseppina

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AB - Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer.

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The "Two-Faced" effects of reactive oxygen species and the lipid peroxidation product 4-Hydroxynonenal in the hallmarks of cancer

Abstract

Keywords

ASJC Scopus subject areas

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