TY - JOUR
T1 - Toward nodal staging of axillary lymph node basins through intradermal administration of fluorescent imaging agents
AU - Meric-Bernstam, Funda
AU - Rasmussen, John C.
AU - Krishnamurthy, Savitri
AU - Tan, I. Chih
AU - Zhu, Banghe
AU - Wagner, Jamie L.
AU - Babiera, Gildy V.
AU - Mittendorf, Elizabeth A.
AU - Sevick-Muraca, Eva M.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - As part of a proof-of-concept study for future delivery of targeted near-infrared fluorescent (NIRF) tracers, we sought to assess the delivery of micrograms of indocyanine green to all the axillary lymph nodes following intraparenchymal breast injections and intradermal arm injections in 20 subjects with advanced breast carcinoma and undergoing complete axillary lymph node dissection. Lymphatic vessels and nodes were assessed in vivo. Ex vivo images demonstrated that 87% of excised lymph nodes, including 81% of tumor-positive lymph nodes, were fluorescent. Future clinical studies using microdose amounts of tumor-targeting NIRF contrast agents may demonstrate improved surgical intervention with reduced morbidity.
AB - As part of a proof-of-concept study for future delivery of targeted near-infrared fluorescent (NIRF) tracers, we sought to assess the delivery of micrograms of indocyanine green to all the axillary lymph nodes following intraparenchymal breast injections and intradermal arm injections in 20 subjects with advanced breast carcinoma and undergoing complete axillary lymph node dissection. Lymphatic vessels and nodes were assessed in vivo. Ex vivo images demonstrated that 87% of excised lymph nodes, including 81% of tumor-positive lymph nodes, were fluorescent. Future clinical studies using microdose amounts of tumor-targeting NIRF contrast agents may demonstrate improved surgical intervention with reduced morbidity.
UR - http://www.scopus.com/inward/record.url?scp=84890861579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890861579&partnerID=8YFLogxK
U2 - 10.1364/BOE.5.000183
DO - 10.1364/BOE.5.000183
M3 - Article
C2 - 24466486
AN - SCOPUS:84890861579
SN - 2156-7085
VL - 5
SP - 183
EP - 196
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 1
ER -