Trouble at the core: BRAF(V600E) drives multiple modes of T-cell suppression in melanoma

Sherille D. Bradley; Brenda Melendez; Amjad Talukder; Gregory Lizée

doi:10.1080/2162402X.2015.1078966

Trouble at the core: BRAF(V600E) drives multiple modes of T-cell suppression in melanoma

Sherille D. Bradley, Brenda Melendez, Amjad Talukder, Gregory Lizée

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Several studies have demonstrated that oncogenic BRAF^(V600E) promotes T-cell suppression in melanoma by upregulating the transcription of a multitude of immunomodulatory chemokine and cytokine genes. BRAF^(V600E) has now been shown to act even more directly to evade cytotoxic T-cell recognition, by driving rapid internalization of human leukocyte antigen (HLA) class I from the tumor-cell surface and its intracellular sequestration.

Original language	English (US)
Journal	OncoImmunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1080/2162402X.2015.1078966
State	Published - Feb 1 2016

Keywords

BRAF V600E
Cancer
Cytotoxic T cell
HLA
MHC class I
immune suppression
immunotherapy
interleukin-1
melanoma
oncogene
oncogene targeted therapies

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2015.1078966

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title = "Trouble at the core: BRAF(V600E) drives multiple modes of T-cell suppression in melanoma",

abstract = "Several studies have demonstrated that oncogenic BRAF(V600E) promotes T-cell suppression in melanoma by upregulating the transcription of a multitude of immunomodulatory chemokine and cytokine genes. BRAF(V600E) has now been shown to act even more directly to evade cytotoxic T-cell recognition, by driving rapid internalization of human leukocyte antigen (HLA) class I from the tumor-cell surface and its intracellular sequestration.",

keywords = "BRAF V600E, Cancer, Cytotoxic T cell, HLA, MHC class I, immune suppression, immunotherapy, interleukin-1, melanoma, oncogene, oncogene targeted therapies",

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AU - Talukder, Amjad

AU - Lizée, Gregory

PY - 2016/2/1

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AB - Several studies have demonstrated that oncogenic BRAF(V600E) promotes T-cell suppression in melanoma by upregulating the transcription of a multitude of immunomodulatory chemokine and cytokine genes. BRAF(V600E) has now been shown to act even more directly to evade cytotoxic T-cell recognition, by driving rapid internalization of human leukocyte antigen (HLA) class I from the tumor-cell surface and its intracellular sequestration.

KW - BRAF V600E

KW - Cancer

KW - Cytotoxic T cell

KW - HLA

KW - MHC class I

KW - immune suppression

KW - immunotherapy

KW - interleukin-1

KW - melanoma

KW - oncogene

KW - oncogene targeted therapies

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Trouble at the core: BRAF(V600E) drives multiple modes of T-cell suppression in melanoma

Abstract

Keywords

ASJC Scopus subject areas

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