Ubiquitin and ubiquitin-like modifications of the p53 family

Ian R. Watson; Meredith S. Irwin

doi:10.1593/neo.06439

Ubiquitin and ubiquitin-like modifications of the p53 family

Ian R. Watson, Meredith S. Irwin

Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.

Original language	English (US)
Pages (from-to)	655-666
Number of pages	12
Journal	Neoplasia
Volume	8
Issue number	8
DOIs	https://doi.org/10.1593/neo.06439
State	Published - 2006

Keywords

NEDD8
SUMO
Ubiquitin
p63
p73

ASJC Scopus subject areas

Cancer Research

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10.1593/neo.06439

Cite this

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title = "Ubiquitin and ubiquitin-like modifications of the p53 family",

abstract = "Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.",

keywords = "NEDD8, SUMO, Ubiquitin, p63, p73",

author = "Watson, {Ian R.} and Irwin, {Meredith S.}",

note = "Funding Information: Address all correspondence to: Dr. Meredith Irwin, Division of Hematology–Oncology, Hospital for Sick Children, Black Wing, 9th Floor, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. E-mail: meredith.irwin@sickkids.ca 1This work was supported by the Terry Fox Foundation of the National Cancer Institute of Canada. M.S.I. is a recipient of the Canada Research Chair. Received 9 June 2006; Revised 9 June 2006; Accepted 9 June 2006.",

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AU - Irwin, Meredith S.

N1 - Funding Information: Address all correspondence to: Dr. Meredith Irwin, Division of Hematology–Oncology, Hospital for Sick Children, Black Wing, 9th Floor, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. E-mail: meredith.irwin@sickkids.ca 1This work was supported by the Terry Fox Foundation of the National Cancer Institute of Canada. M.S.I. is a recipient of the Canada Research Chair. Received 9 June 2006; Revised 9 June 2006; Accepted 9 June 2006.

PY - 2006

Y1 - 2006

N2 - Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.

AB - Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.

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KW - Ubiquitin

KW - p63

KW - p73

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Ubiquitin and ubiquitin-like modifications of the p53 family

Abstract

Keywords

ASJC Scopus subject areas

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