Abstract
Genome integrity is constantly challenged by various DNA lesions with DNA double-strand breaks (DSBs) as the most cytotoxic lesions. In order to faithfully repair DSBs, DNA damage response (DDR) signaling networks have evolved, which organize many multi-protein complexes to deal with the encountered DNA damage. Spatiotemporal dynamics of these protein complexes at DSBs are mainly modulated by post-translational modifications (PTMs). One of the most well-studied PTMs in DDR is ubiquitylation which can orchestrate cellular responses to DSBs, promote accurate DNA repair, and maintain genome integrity. Here, we summarize the recent advances of ubiquitin-dependent signaling in DDR and discuss how ubiquitylation crosstalks with other PTMs to control fundamental biological processes in DSB repair.
Original language | English (US) |
---|---|
Article number | 103129 |
Journal | DNA Repair |
Volume | 103 |
DOIs | |
State | Published - Jul 2021 |
Keywords
- DNA damage response
- Double strand break
- homologous recombination (HR)
- non-homologous end joining (NHEJ)
- ubiquitylation
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology