TY - JOUR
T1 - Unveiling HPV's hidden link
T2 - Cardiovascular diseases and the viral intrigue
AU - Dutta, Preyangsee
AU - Saha, Dwaipayan
AU - Earle, Mrudul
AU - Prasad, Chandra Prakash
AU - Singh, Mayank
AU - Darswal, Mrinalini
AU - Aggarwal, Vipul
AU - Naik, Nitish
AU - Yadav, Rakesh
AU - Shankar, Abhishek
AU - Chakraborty, Abhijit
N1 - Publisher Copyright:
© 2024
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Cardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV, a prevalent sexually transmitted infection, as a potential unconventional risk factor for CVD. This review delves into the underlying mechanisms linking HPV to CVD pathogenesis. HPV's influence on vascular endothelium and induction of systemic inflammation are key contributors. Additionally, HPV disrupts host lipid metabolism, further exacerbating the development of atherosclerosis. The link between HPV and CAD is not merely correlative; it encompasses a complex interplay of virological, immunological, and metabolic factors. Understanding the connection between HPV and CVD holds transformative potential. Insights from this review not only underscore the significance of considering HPV as a crucial risk factor but also advocate for targeted HPV screening and vaccination strategies to mitigate CVD risks. This multidisciplinary exploration bridges the gap between infectious diseases and cardiovascular health, emphasizing the need for a comprehensive approach to combating the global burden of cardiovascular disease. Further research and clinical guidelines in this realm are essential to harness the full scope of preventive and therapeutic interventions, ultimately shaping a healthier cardiovascular landscape.
AB - Cardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV, a prevalent sexually transmitted infection, as a potential unconventional risk factor for CVD. This review delves into the underlying mechanisms linking HPV to CVD pathogenesis. HPV's influence on vascular endothelium and induction of systemic inflammation are key contributors. Additionally, HPV disrupts host lipid metabolism, further exacerbating the development of atherosclerosis. The link between HPV and CAD is not merely correlative; it encompasses a complex interplay of virological, immunological, and metabolic factors. Understanding the connection between HPV and CVD holds transformative potential. Insights from this review not only underscore the significance of considering HPV as a crucial risk factor but also advocate for targeted HPV screening and vaccination strategies to mitigate CVD risks. This multidisciplinary exploration bridges the gap between infectious diseases and cardiovascular health, emphasizing the need for a comprehensive approach to combating the global burden of cardiovascular disease. Further research and clinical guidelines in this realm are essential to harness the full scope of preventive and therapeutic interventions, ultimately shaping a healthier cardiovascular landscape.
KW - Atherosclerosis
KW - Cardiovascular diseases (CVD)
KW - Human papillomavirus (HPV)
KW - Screening and vaccination strategies
KW - Unconventional risk factor
KW - Vascular endothelium
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UR - http://www.scopus.com/inward/citedby.url?scp=85186841178&partnerID=8YFLogxK
U2 - 10.1016/j.ihj.2024.02.001
DO - 10.1016/j.ihj.2024.02.001
M3 - Editorial
C2 - 38387552
AN - SCOPUS:85186841178
SN - 0019-4832
VL - 76
SP - 1
EP - 5
JO - Indian Heart Journal
JF - Indian Heart Journal
IS - 1
ER -