Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence

Abdullah A. Osman, Marcus M. Monroe, Marcus V. Ortega Alves, Ameeta A. Patel, Panagiotis Katsonis, Alison L. Fitzgerald, David M. Neskey, Mitchell J. Frederick, Sang Hyeok Woo, Carlos Caulin, Teng Kuei Hsu, Thomas O. McDonald, Marek Kimmel, Raymond E. Meyn, Olivier Lichtarge, Jeffrey N. Myers

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Medicine & Life Sciences