ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan; Ren Ren; Ruopeng Feng; Lana C. Ly; Yemin Lan; Zhe Zhang; Nicholas Aboreden; Kunhua Qin; John R. Horton; Jeremy D. Grevet; Thiyagaraj Mayuranathan; Osheiza Abdulmalik; Cheryl A. Keller; Belinda Giardine; Ross C. Hardison; Merlin Crossley; Mitchell J. Weiss; Xiaodong Cheng; Junwei Shi; Gerd A. Blobel

doi:10.1016/j.molcel.2020.11.006

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C. Ly, Yemin Lan, Zhe Zhang, Nicholas Aboreden, Kunhua Qin, John R. Horton, Jeremy D. Grevet, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Merlin Crossley, Mitchell J. Weiss, Xiaodong Cheng, Junwei Shi, Gerd A. Blobel

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

Original language	English (US)
Pages (from-to)	239-254.e8
Journal	Molecular cell
Volume	81
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2020.11.006
State	Published - Jan 21 2021

Keywords

CHD4
CRISPR screen
NuRD
ZNF410
erythroid biology
fetal hemoglobin
hemoglobin switching
sickle cell disease
transcription
transcription factor

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2020.11.006

Cite this

Lan, X., Ren, R., Feng, R., Ly, L. C., Lan, Y., Zhang, Z., Aboreden, N., Qin, K., Horton, J. R., Grevet, J. D., Mayuranathan, T., Abdulmalik, O., Keller, C. A., Giardine, B., Hardison, R. C., Crossley, M., Weiss, M. J., Cheng, X., Shi, J., & Blobel, G. A. (2021). ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Molecular cell, 81(2), 239-254.e8. https://doi.org/10.1016/j.molcel.2020.11.006

Lan, X, Ren, R, Feng, R, Ly, LC, Lan, Y, Zhang, Z, Aboreden, N, Qin, K, Horton, JR, Grevet, JD, Mayuranathan, T, Abdulmalik, O, Keller, CA, Giardine, B, Hardison, RC, Crossley, M, Weiss, MJ, Cheng, X, Shi, J & Blobel, GA 2021, 'ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression', Molecular cell, vol. 81, no. 2, pp. 239-254.e8. https://doi.org/10.1016/j.molcel.2020.11.006

@article{d069fe0abb9c4377a73a3502d7941ac8,

title = "ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression",

abstract = "Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.",

keywords = "CHD4, CRISPR screen, NuRD, ZNF410, erythroid biology, fetal hemoglobin, hemoglobin switching, sickle cell disease, transcription, transcription factor",

author = "Xianjiang Lan and Ren Ren and Ruopeng Feng and Ly, {Lana C.} and Yemin Lan and Zhe Zhang and Nicholas Aboreden and Kunhua Qin and Horton, {John R.} and Grevet, {Jeremy D.} and Thiyagaraj Mayuranathan and Osheiza Abdulmalik and Keller, {Cheryl A.} and Belinda Giardine and Hardison, {Ross C.} and Merlin Crossley and Weiss, {Mitchell J.} and Xiaodong Cheng and Junwei Shi and Blobel, {Gerd A.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jan,

day = "21",

doi = "10.1016/j.molcel.2020.11.006",

language = "English (US)",

volume = "81",

pages = "239--254.e8",

journal = "Molecular cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

AU - Lan, Xianjiang

AU - Ren, Ren

AU - Feng, Ruopeng

AU - Ly, Lana C.

AU - Lan, Yemin

AU - Zhang, Zhe

AU - Aboreden, Nicholas

AU - Qin, Kunhua

AU - Horton, John R.

AU - Grevet, Jeremy D.

AU - Mayuranathan, Thiyagaraj

AU - Abdulmalik, Osheiza

AU - Keller, Cheryl A.

AU - Giardine, Belinda

AU - Hardison, Ross C.

AU - Crossley, Merlin

AU - Weiss, Mitchell J.

AU - Cheng, Xiaodong

AU - Shi, Junwei

AU - Blobel, Gerd A.

PY - 2021/1/21

Y1 - 2021/1/21

N2 - Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

AB - Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

KW - CHD4

KW - CRISPR screen

KW - NuRD

KW - ZNF410

KW - erythroid biology

KW - fetal hemoglobin

KW - hemoglobin switching

KW - sickle cell disease

KW - transcription

KW - transcription factor

UR - http://www.scopus.com/inward/record.url?scp=85098119358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85098119358&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2020.11.006

DO - 10.1016/j.molcel.2020.11.006

M3 - Article

C2 - 33301730

AN - SCOPUS:85098119358

SN - 1097-2765

VL - 81

SP - 239-254.e8

JO - Molecular cell

JF - Molecular cell

IS - 2

ER -

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this